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Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation
Lesions were induced in the lungs of specific-pathogen-free F344 rats by chronic tobacco smoke exposure. Animals exposed to 7 cigarettes/day were killed after 1, 1.5, or 2 years of exposure. Parallel lifetime exposures induced pulmonary tumors in 9% of the animals. In serially killed animals, four t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
1982
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204517/ https://www.ncbi.nlm.nih.gov/pubmed/6954304 http://dx.doi.org/10.1093/jnci/69.1.117 |
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author | Heckman, Carol A. Dalbey, Walden E. |
author_facet | Heckman, Carol A. Dalbey, Walden E. |
author_sort | Heckman, Carol A. |
collection | PubMed |
description | Lesions were induced in the lungs of specific-pathogen-free F344 rats by chronic tobacco smoke exposure. Animals exposed to 7 cigarettes/day were killed after 1, 1.5, or 2 years of exposure. Parallel lifetime exposures induced pulmonary tumors in 9% of the animals. In serially killed animals, four types of lesions were found: 1) perivascular or peribronchiolar accumulation of lymphoreticular cells, 2) fibrotic and cellular enlargement of peribronchiolar septa, 3) type II cell hyperplasia with septal fibrosis, and 4) air-space enlargement (emphysema). However, emphysema occurred only in animals exposed to a higher (10 cigarettes) dose of tobacco smoke. Ultrastructural studies showed all of the focal lesions to be infiltrated by cells typical of the inflammatory response. The type II hyperplastic and peribronchiolar alveolar lesions involved larger portions of the parenchyma in fibrotic changes but differed in structure, location, and frequency. The incidence of the peribronchiolar alveolar lesions was temporally related to tumor incidence. |
format | Online Article Text |
id | pubmed-7204517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1982 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-72045172020-05-08 Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation Heckman, Carol A. Dalbey, Walden E. J Natl Cancer Inst Investigations on Nonhuman Systems Lesions were induced in the lungs of specific-pathogen-free F344 rats by chronic tobacco smoke exposure. Animals exposed to 7 cigarettes/day were killed after 1, 1.5, or 2 years of exposure. Parallel lifetime exposures induced pulmonary tumors in 9% of the animals. In serially killed animals, four types of lesions were found: 1) perivascular or peribronchiolar accumulation of lymphoreticular cells, 2) fibrotic and cellular enlargement of peribronchiolar septa, 3) type II cell hyperplasia with septal fibrosis, and 4) air-space enlargement (emphysema). However, emphysema occurred only in animals exposed to a higher (10 cigarettes) dose of tobacco smoke. Ultrastructural studies showed all of the focal lesions to be infiltrated by cells typical of the inflammatory response. The type II hyperplastic and peribronchiolar alveolar lesions involved larger portions of the parenchyma in fibrotic changes but differed in structure, location, and frequency. The incidence of the peribronchiolar alveolar lesions was temporally related to tumor incidence. Oxford University Press 1982-07-01 /pmc/articles/PMC7204517/ /pubmed/6954304 http://dx.doi.org/10.1093/jnci/69.1.117 Text en https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
spellingShingle | Investigations on Nonhuman Systems Heckman, Carol A. Dalbey, Walden E. Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation |
title | Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation |
title_full | Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation |
title_fullStr | Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation |
title_full_unstemmed | Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation |
title_short | Pathogenesis of Lesions Induced in Rat Lung by Chronic Tobacco Smoke Inhalation |
title_sort | pathogenesis of lesions induced in rat lung by chronic tobacco smoke inhalation |
topic | Investigations on Nonhuman Systems |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204517/ https://www.ncbi.nlm.nih.gov/pubmed/6954304 http://dx.doi.org/10.1093/jnci/69.1.117 |
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