AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context...

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Detalles Bibliográficos
Autores principales: Tang, Catherine, Bagnara, Davide, Chiorazzi, Nicholas, Scharff, Matthew D., MacCarthy, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204545/
https://www.ncbi.nlm.nih.gov/pubmed/32425948
http://dx.doi.org/10.3389/fimmu.2020.00788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204545/
https://www.ncbi.nlm.nih.gov/pubmed/32425948
http://dx.doi.org/10.3389/fimmu.2020.00788

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