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Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection

Following the large outbreak of Zika virus in the Western Hemisphere, many infants have been born with congenital Zika virus infection. It is important to describe the functional outcomes seen with congenital infections to allow for their recognition and appropriate interventions. We evaluated 120 c...

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Autores principales: Bertolli, Jeanne, Attell, Jacob Elijah, Rose, Charles, Moore, Cynthia A., Melo, Flávio, Staples, Jennifer Erin, Kotzky, Kim, Krishna, Nevin, Satterfield-Nash, Ashley, Pereira, Isabela Ornelas, Pessoa, André, Smith, Donna Camille, Santelli, Ana Carolina Faria e Silva, Boyle, Coleen A., Peacock, Georgina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204564/
https://www.ncbi.nlm.nih.gov/pubmed/32228785
http://dx.doi.org/10.4269/ajtmh.19-0961
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author Bertolli, Jeanne
Attell, Jacob Elijah
Rose, Charles
Moore, Cynthia A.
Melo, Flávio
Staples, Jennifer Erin
Kotzky, Kim
Krishna, Nevin
Satterfield-Nash, Ashley
Pereira, Isabela Ornelas
Pessoa, André
Smith, Donna Camille
Santelli, Ana Carolina Faria e Silva
Boyle, Coleen A.
Peacock, Georgina
author_facet Bertolli, Jeanne
Attell, Jacob Elijah
Rose, Charles
Moore, Cynthia A.
Melo, Flávio
Staples, Jennifer Erin
Kotzky, Kim
Krishna, Nevin
Satterfield-Nash, Ashley
Pereira, Isabela Ornelas
Pessoa, André
Smith, Donna Camille
Santelli, Ana Carolina Faria e Silva
Boyle, Coleen A.
Peacock, Georgina
author_sort Bertolli, Jeanne
collection PubMed
description Following the large outbreak of Zika virus in the Western Hemisphere, many infants have been born with congenital Zika virus infection. It is important to describe the functional outcomes seen with congenital infections to allow for their recognition and appropriate interventions. We evaluated 120 children conceived during the 2015–2016 Zika virus outbreak in Paraíba, Brazil, who were approximately 24 months old, to assess functional outcomes. All children met either anthropometric criteria or laboratory criteria suggestive of possible congenital Zika virus infection. We collected results of previous medical evaluations, interviewed parents, and performed physical examinations and functional assessments, for example, the Hammersmith Infant Neurological Examination (HINE). We compared patterns of neurologic outcomes and developmental delay at age 24 months by whether children met anthropometric or laboratory criteria, or both. Among children meeting both criteria, 60% (26/43) were multiply affected (had severe motor impairment, severe developmental delay, and suboptimal HINE scores), compared with 5% (3/57) meeting only laboratory criteria and none (0/20) meeting only anthropometric criteria. Of the remaining 91 children, 49% (45) had developmental delay, with more severe delay seen in children meeting both criteria. Although children meeting physical and laboratory criteria for potential congenital Zika virus infection were more severely affected, we did identify several children with notable adverse neurologic outcomes and developmental delay with no physical findings but potential laboratory evidence of Zika virus infection. Given this, all children who were potentially exposed in utero to Zika virus should be monitored in early childhood for deficits to allow for early intervention.
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spelling pubmed-72045642020-05-07 Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection Bertolli, Jeanne Attell, Jacob Elijah Rose, Charles Moore, Cynthia A. Melo, Flávio Staples, Jennifer Erin Kotzky, Kim Krishna, Nevin Satterfield-Nash, Ashley Pereira, Isabela Ornelas Pessoa, André Smith, Donna Camille Santelli, Ana Carolina Faria e Silva Boyle, Coleen A. Peacock, Georgina Am J Trop Med Hyg Articles Following the large outbreak of Zika virus in the Western Hemisphere, many infants have been born with congenital Zika virus infection. It is important to describe the functional outcomes seen with congenital infections to allow for their recognition and appropriate interventions. We evaluated 120 children conceived during the 2015–2016 Zika virus outbreak in Paraíba, Brazil, who were approximately 24 months old, to assess functional outcomes. All children met either anthropometric criteria or laboratory criteria suggestive of possible congenital Zika virus infection. We collected results of previous medical evaluations, interviewed parents, and performed physical examinations and functional assessments, for example, the Hammersmith Infant Neurological Examination (HINE). We compared patterns of neurologic outcomes and developmental delay at age 24 months by whether children met anthropometric or laboratory criteria, or both. Among children meeting both criteria, 60% (26/43) were multiply affected (had severe motor impairment, severe developmental delay, and suboptimal HINE scores), compared with 5% (3/57) meeting only laboratory criteria and none (0/20) meeting only anthropometric criteria. Of the remaining 91 children, 49% (45) had developmental delay, with more severe delay seen in children meeting both criteria. Although children meeting physical and laboratory criteria for potential congenital Zika virus infection were more severely affected, we did identify several children with notable adverse neurologic outcomes and developmental delay with no physical findings but potential laboratory evidence of Zika virus infection. Given this, all children who were potentially exposed in utero to Zika virus should be monitored in early childhood for deficits to allow for early intervention. The American Society of Tropical Medicine and Hygiene 2020-05 2020-03-30 /pmc/articles/PMC7204564/ /pubmed/32228785 http://dx.doi.org/10.4269/ajtmh.19-0961 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Bertolli, Jeanne
Attell, Jacob Elijah
Rose, Charles
Moore, Cynthia A.
Melo, Flávio
Staples, Jennifer Erin
Kotzky, Kim
Krishna, Nevin
Satterfield-Nash, Ashley
Pereira, Isabela Ornelas
Pessoa, André
Smith, Donna Camille
Santelli, Ana Carolina Faria e Silva
Boyle, Coleen A.
Peacock, Georgina
Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection
title Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection
title_full Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection
title_fullStr Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection
title_full_unstemmed Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection
title_short Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection
title_sort functional outcomes among a cohort of children in northeastern brazil meeting criteria for follow-up of congenital zika virus infection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204564/
https://www.ncbi.nlm.nih.gov/pubmed/32228785
http://dx.doi.org/10.4269/ajtmh.19-0961
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