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From SARS to COVID-19: What we have learned about children infected with COVID-19

INTRODUCTION: Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain biological, epidemiological and pathological similarities. To date, research has shown that their genes exhibit 79% of identical sequences and the receptor-binding domain structure is also very simi...

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Autores principales: Zhou, Meng-Yao, Xie, Xiao-Li, Peng, Yong-Gang, Wu, Meng-Jun, Deng, Xiao-Zhi, Wu, Ying, Xiong, Li-Jing, Shang, Li-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204709/
https://www.ncbi.nlm.nih.gov/pubmed/32389849
http://dx.doi.org/10.1016/j.ijid.2020.04.090
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author Zhou, Meng-Yao
Xie, Xiao-Li
Peng, Yong-Gang
Wu, Meng-Jun
Deng, Xiao-Zhi
Wu, Ying
Xiong, Li-Jing
Shang, Li-Hong
author_facet Zhou, Meng-Yao
Xie, Xiao-Li
Peng, Yong-Gang
Wu, Meng-Jun
Deng, Xiao-Zhi
Wu, Ying
Xiong, Li-Jing
Shang, Li-Hong
author_sort Zhou, Meng-Yao
collection PubMed
description INTRODUCTION: Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain biological, epidemiological and pathological similarities. To date, research has shown that their genes exhibit 79% of identical sequences and the receptor-binding domain structure is also very similar. There has been extensive research performed on SARS; however, the understanding of the pathophysiological impact of coronavirus disease 2019 (COVID-19) is still limited. METHODS: This review drew upon the lessons learnt from SARS, in terms of epidemiology, clinical characteristics and pathogenesis, to further understand the features of COVID-19. RESULTS: By comparing these two diseases, it found that COVID-19 has quicker and wider transmission, obvious family agglomeration, and higher morbidity and mortality. Newborns, asymptomatic children and normal chest imaging cases emerged in COVID-19 literature. Children starting with gastrointestinal symptoms may progress to severe conditions and newborns whose mothers are infected with COVID-19 could have severe complications. The laboratory test data showed that the percentage of neutrophils and the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19 cases. CONCLUSION: Based on these early observations, as pediatricians, this review put forward some thoughts on children's COVID-19 and gave some recommendations to contain the disease.
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spelling pubmed-72047092020-05-07 From SARS to COVID-19: What we have learned about children infected with COVID-19 Zhou, Meng-Yao Xie, Xiao-Li Peng, Yong-Gang Wu, Meng-Jun Deng, Xiao-Zhi Wu, Ying Xiong, Li-Jing Shang, Li-Hong Int J Infect Dis Article INTRODUCTION: Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain biological, epidemiological and pathological similarities. To date, research has shown that their genes exhibit 79% of identical sequences and the receptor-binding domain structure is also very similar. There has been extensive research performed on SARS; however, the understanding of the pathophysiological impact of coronavirus disease 2019 (COVID-19) is still limited. METHODS: This review drew upon the lessons learnt from SARS, in terms of epidemiology, clinical characteristics and pathogenesis, to further understand the features of COVID-19. RESULTS: By comparing these two diseases, it found that COVID-19 has quicker and wider transmission, obvious family agglomeration, and higher morbidity and mortality. Newborns, asymptomatic children and normal chest imaging cases emerged in COVID-19 literature. Children starting with gastrointestinal symptoms may progress to severe conditions and newborns whose mothers are infected with COVID-19 could have severe complications. The laboratory test data showed that the percentage of neutrophils and the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19 cases. CONCLUSION: Based on these early observations, as pediatricians, this review put forward some thoughts on children's COVID-19 and gave some recommendations to contain the disease. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-07 2020-05-07 /pmc/articles/PMC7204709/ /pubmed/32389849 http://dx.doi.org/10.1016/j.ijid.2020.04.090 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhou, Meng-Yao
Xie, Xiao-Li
Peng, Yong-Gang
Wu, Meng-Jun
Deng, Xiao-Zhi
Wu, Ying
Xiong, Li-Jing
Shang, Li-Hong
From SARS to COVID-19: What we have learned about children infected with COVID-19
title From SARS to COVID-19: What we have learned about children infected with COVID-19
title_full From SARS to COVID-19: What we have learned about children infected with COVID-19
title_fullStr From SARS to COVID-19: What we have learned about children infected with COVID-19
title_full_unstemmed From SARS to COVID-19: What we have learned about children infected with COVID-19
title_short From SARS to COVID-19: What we have learned about children infected with COVID-19
title_sort from sars to covid-19: what we have learned about children infected with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204709/
https://www.ncbi.nlm.nih.gov/pubmed/32389849
http://dx.doi.org/10.1016/j.ijid.2020.04.090
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