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ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy

BACKGROUND: Interleukin-2 (IL-2) plays a pivotal role in immune homeostasis due to its ability to stimulate numerous lymphocyte subsets including natural killer (NK) cells, effector CD4(+) and CD8(+) T cells, and regulatory T cells (T(regs)). Low concentrations of IL-2 induce signaling through the h...

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Detalles Bibliográficos
Autores principales:	Lopes, Jared E, Fisher, Jan L, Flick, Heather L, Wang, Chunhua, Sun, Lei, Ernstoff, Marc S, Alvarez, Juan C, Losey, Heather C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204809/ https://www.ncbi.nlm.nih.gov/pubmed/32317293 http://dx.doi.org/10.1136/jitc-2020-000673

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