Association of smokeless tobacco with oral cancer: A review of systematic reviews

INTRODUCTION: Various primary studies and systematic reviews have been conducted to explain the association between smokeless tobacco and oral cancer. This study aims to consolidate and summarize the risk estimates from various systematic reviews with or without meta-analysis to provide the spectrum of estimates on the association between smokeless tobacco use and oral cancer. METHODS: A comprehensive literature search was done on various databases (PubMed, Google Scholar, IndMED, and TOXLINE) by two of the authors independently. Both qualitative and quantitative data extraction and analysis were performed for the included systematic reviews. Range of risk estimates was obtained and analyzed as quantitative findings due to the limitation of an overview of reviews for the pooled estimates. CASP (Critical Appraisals Skills Programme) and AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews) tools were used for the quality assessment of the studies included. RESULTS: In total, 12 systematic reviews with or without meta-analysis were included in the review. There was a positive and strong association of Smokeless Tobacco (SLT) use with oral cancer irrespective of gender, region, and type of smokeless tobacco. The risk estimate for the South–East Asia Region (SEAR) ranged 4.44–7.90, for Gutkha it was 8.67, while for Paan it ranged 6.3–7.90 and for overall SLT it ranged 1.36–7.90. Risk estimate for females ranged 5.83–14.56. CONCLUSIONS: The study confirmed the association between SLT use and oral cancer. These findings are of high importance, especially to the South-East Asia Region.