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Accurate Inference of Tumor Purity and Absolute Copy Numbers From High-Throughput Sequencing Data
Inference of absolute copy numbers in tumor genomes is one of the key points in the study of tumor genesis. However, the mixture of tumor and normal cells poses a big challenge to this task. Accurate estimation of tumor purity (i.e., the fraction of tumor cells) is a necessary step to solve this pro...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205152/ https://www.ncbi.nlm.nih.gov/pubmed/32425990 http://dx.doi.org/10.3389/fgene.2020.00458 |