Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design

For an antibody to be a successful therapeutic many competing factors require optimization, including binding affinity, biophysical characteristics, and immunogenicity risk. Additional constraints may arise from the need to formulate antibodies at high concentrations (>150 mg/ml) to enable subcut...

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Detalles Bibliográficos
Autores principales: Apgar, James R., Tam, Amy S. P., Sorm, Rhady, Moesta, Sybille, King, Amy C., Yang, Han, Kelleher, Kerry, Murphy, Denise, D’Antona, Aaron M., Yan, Guoying, Zhong, Xiaotian, Rodriguez, Linette, Ma, Weijun, Ferguson, Darren E., Carven, Gregory J., Bennett, Eric M., Lin, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205207/
https://www.ncbi.nlm.nih.gov/pubmed/32379792
http://dx.doi.org/10.1371/journal.pone.0232713

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