Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding

Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a viable option for highly specific HIV-1 therapy. The INSTI, Dolutegravir is re...

Descripción completa

Detalles Bibliográficos
Autores principales: Chitongo, Rumbidzai, Obasa, Adetayo Emmanuel, Mikasi, Sello Given, Jacobs, Graeme Brendon, Cloete, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205217/
https://www.ncbi.nlm.nih.gov/pubmed/32379830
http://dx.doi.org/10.1371/journal.pone.0223464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205217/
https://www.ncbi.nlm.nih.gov/pubmed/32379830
http://dx.doi.org/10.1371/journal.pone.0223464

Ejemplares similares