Cargando…

Mycotoxin Altertoxin II Induces Lipid Peroxidation Connecting Mitochondrial Stress Response to NF-κB Inhibition in THP-1 Macrophages

[Image: see text] Prolonged exposure to mycotoxins, even in subtoxic concentrations, might contribute to modulate pro- or anti-inflammatory cascades and ultimately have long-term consequences on our health. In line, there is an increasing need to describe and comprehend the potential immunomodulator...

Descripción completa

Detalles Bibliográficos
Autores principales:	Del Favero, Giorgia, Hohenbichler, Julia, Mayer, Raphaela Maria, Rychlik, Michael, Marko, Doris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205407/ https://www.ncbi.nlm.nih.gov/pubmed/32022557 http://dx.doi.org/10.1021/acs.chemrestox.9b00378

Ejemplares similares

Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II
por: Jarolim, Katharina, et al.
Publicado: (2016)

Functional impairment triggered by altertoxin II (ATXII) in intestinal cells in vitro: cross-talk between cytotoxicity and mechanotransduction
por: Del Favero, Giorgia, et al.
Publicado: (2018)

The mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation in THP-1 derived macrophages targeting the NF-κB signalling pathway
por: Kollarova, Jessica, et al.
Publicado: (2018)

Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro
por: Hohenbichler, Julia, et al.
Publicado: (2020)

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function
por: Del Favero, Giorgia, et al.
Publicado: (2021)

The Fate of Altertoxin II During Tomato Processing Steps at a Laboratory Scale
por: Puntscher, Hannes, et al.
Publicado: (2019)

Markers for DNA damage are induced in the rat colon by the Alternaria toxin altertoxin-II, but not a complex extract of cultured Alternaria alternata
por: Aichinger, Georg, et al.
Publicado: (2022)

Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol
por: Del Favero, Giorgia, et al.
Publicado: (2020)

Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells
por: Groestlinger, Julia, et al.
Publicado: (2022)

Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma
por: Robles, Andrew J., et al.
Publicado: (2021)

Proposal of a comprehensive definition of modified and other forms of mycotoxins including “masked” mycotoxins
por: Rychlik, Michael, et al.
Publicado: (2014)

Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase
por: Jarolim, Katharina, et al.
Publicado: (2016)

Immunomodulatory Properties of Blackberry Anthocyanins in THP-1 Derived Macrophages
por: Cenk, Ebru, et al.
Publicado: (2021)

Protein arginine methyltransferase 5 mediates THP-1-derived macrophage activation dependent on NF-κB in endometriosis
por: Chai, Xiaoshan, et al.
Publicado: (2021)

Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage
por: Oliveira, Douglas Souza, et al.
Publicado: (2021)

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
por: Zhang, Fei, et al.
Publicado: (2020)

Octanoylated Ghrelin Inhibits the Activation of the Palmitic Acid-Induced TLR4/NF-κB Signaling Pathway in THP-1 Macrophages
por: Liu, S. P., et al.
Publicado: (2012)

Anti-Inflammatory Effects of Camellia fascicularis Polyphenols via Attenuation of NF-κB and MAPK Pathways in LPS-Induced THP-1 Macrophages
por: Gao, Miaozi, et al.
Publicado: (2022)

Regulation of NF-κB-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes
por: Yadav, Umesh C. S., et al.
Publicado: (2013)

A critical evaluation of health risk assessment of modified mycotoxins with a special focus on zearalenone
por: Lorenz, Nicole, et al.
Publicado: (2018)

Oleacein Attenuates Lipopolysaccharide-Induced Inflammation in THP-1-Derived Macrophages by the Inhibition of TLR4/MyD88/NF-κB Pathway †
por: Cirmi, Santa, et al.
Publicado: (2022)

Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells
por: Somma, Domenico, et al.
Publicado: (2021)

Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages
por: Zhao, Weiming, et al.
Publicado: (2019)

Oncostatin M promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the NF-κB pathway in THP-1 macrophages and promotes the progression of atherosclerosis
por: Liu, Cheng, et al.
Publicado: (2022)

The Protective Effects of Neoastilbin on Monosodium Urate Stimulated THP-1-Derived Macrophages and Gouty Arthritis in Mice through NF-κB and NLRP3 Inflammasome Pathways
por: Xu, Wenjing, et al.
Publicado: (2022)

Effects of Fusarium Mycotoxin Exposure on Lipid Peroxidation and Glutathione Redox System in the Liver of Laying Hens
por: Kulcsár, Szabina, et al.
Publicado: (2021)

TET1 Knockdown Inhibits Porphyromonas gingivalis LPS/IFN-γ-Induced M1 Macrophage Polarization through the NF-κB Pathway in THP-1 Cells
por: Huang, Yanlan, et al.
Publicado: (2019)

Modified Yuejuwan Inhibited Cholesterol Accumulation and Inflammation in THP-1 Macrophage-Derived Foam Cells by Inhibiting the Activity of the TRIM37/TRAF2/NF-κB Pathway
por: Gui, Mingtai, et al.
Publicado: (2022)

NF-κB Potentiates Caspase Independent Hydrogen Peroxide Induced Cell Death
por: Ho, Jessica Q., et al.
Publicado: (2011)

Paeoniflorin reduced BLP-induced inflammatory response by inhibiting the NF-κB signal transduction in pathway THP-1 cells
por: Zhang, Qian, et al.
Publicado: (2014)

Evaluation of the Efficacy of Mycotoxin Modifiers and Mycotoxin Binders by Using an In Vitro Rumen Model as a First Screening Tool
por: Debevere, Sandra, et al.
Publicado: (2020)

Analysis of 13 Alternaria mycotoxins including modified forms in beer
por: Scheibenzuber, Sophie, et al.
Publicado: (2021)

TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination
por: Zhu, Chao, et al.
Publicado: (2022)

Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro
por: Vejdovszky, Katharina, et al.
Publicado: (2016)

IKKβ/NF-κB and the miscreant macrophage
por: Timmer, Anjuli M., et al.
Publicado: (2008)

L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-κB pathway
por: Zhu, Mingzhu, et al.
Publicado: (2015)

The Sonodynamic Effect of Curcumin on THP-1 Cell-Derived Macrophages
por: Wang, Fengping, et al.
Publicado: (2013)

Effects of Benzalkonium Chloride on THP-1 Differentiated Macrophages In Vitro
por: Michée, Sylvain, et al.
Publicado: (2013)

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection
por: Maeß, Marten B., et al.
Publicado: (2014)

Cadmium Alters the Concentration of Fatty Acids in THP-1 Macrophages
por: Olszowski, Tomasz, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_v15j9up5ks368ap1l4kujbrslg