Cargando…

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

The ability of the immune system to avoid autoimmune disease relies on tolerization of thymocytes to self-antigens whose expression and presentation by thymic medullary epithelial cells (mTECs) is controlled predominantly by Aire at the transcriptional level and possibly regulated at other unrecogni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205469/ https://www.ncbi.nlm.nih.gov/pubmed/32338592 http://dx.doi.org/10.7554/eLife.52985

Ejemplares similares

Estrogen-induced upregulation and 3′-UTR shortening of CDC6
por: Akman, Begum H., et al.
Publicado: (2012)

Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer
por: Lembo, Antonio, et al.
Publicado: (2012)

AIRE deficiency, from preclinical models to human APECED disease
por: Besnard, Marine, et al.
Publicado: (2021)

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
por: Kim, Sora, et al.
Publicado: (2020)

3′UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network
por: Li, Li, et al.
Publicado: (2014)

Genome-wide analysis of rice ClpB/HSP100, ClpC and ClpD genes
por: Singh, Amanjot, et al.
Publicado: (2010)

Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells
por: Danan-Gotthold, Miri, et al.
Publicado: (2016)

Collagen-Like Proteins (ClpA, ClpB, ClpC, and ClpD) Are Required for Biofilm Formation and Adhesion to Plant Roots by Bacillus amyloliquefaciens FZB42
por: Zhao, Xia, et al.
Publicado: (2015)

3′UTR shortening of profibrotic genes and reversibility of fibrosis in patients with end‐stage right ventricular failure
por: Neupane, Rahul, et al.
Publicado: (2022)

3’UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension
por: Tseng, Victor, et al.
Publicado: (2022)

Caseinolytic Proteins (Clp) in the Genus Klebsiella: Special Focus on ClpK
por: Motiwala, Tehrim, et al.
Publicado: (2021)

3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells
por: Hoffman, Yonit, et al.
Publicado: (2016)

Shortening of 3′ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism
por: Burri, Dominik, et al.
Publicado: (2021)

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2
por: Benaroudj, Nadia, et al.
Publicado: (2011)

Bioinformatic identification of ClpI, a distinct class of Clp unfoldases in Actinomycetota
por: Jiang, Jialiu, et al.
Publicado: (2023)

The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
por: Leodolter, Julia, et al.
Publicado: (2015)

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
por: Auburger, Georg, et al.
Publicado: (2022)

Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis
por: Reinhardt, Laura, et al.
Publicado: (2022)

Correction: 3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells
Publicado: (2016)

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening
por: Beaudoin, Jean-Denis, et al.
Publicado: (2013)

3′-UTR Shortening Contributes to Subtype-Specific Cancer Growth by Breaking Stable ceRNA Crosstalk of Housekeeping Genes
por: Fan, Zhenjiang, et al.
Publicado: (2020)

Corrigendum: Shortening of 3′ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism
por: Burri, Dominik, et al.
Publicado: (2023)

Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
Publicado: (2015)

Promiscuous Gene Expression in the Thymus: A Matter of Epigenetics, miRNA, and More?
por: Ucar, Olga, et al.
Publicado: (2015)

ClpX eats randomly
por: Wells, William A.
Publicado: (2005)

Comparative roles of clpA and clpB in the survival of S. Typhimurium under stress and virulence in poultry
por: Sangpuii, Lal, et al.
Publicado: (2018)

Can the duration of tuberculosis treatment be shortened with higher dosages of rifampicin?
por: Dutta, Noton K., et al.
Publicado: (2015)

Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells
por: Shi, Xinglong, et al.
Publicado: (2021)

Co-Suppression of NbClpC1 and NbClpC2, Encoding Clp Protease Chaperons, Elicits Significant Changes in the Metabolic Profile of Nicotiana benthamiana
por: Ali, Md. Sarafat, et al.
Publicado: (2020)

The role of ClpX in erythropoietic protoporphyria
por: Whitman, Jared C., et al.
Publicado: (2018)

FNDC3B 3′‐UTR shortening escapes from microRNA‐mediated gene repression and promotes nasopharyngeal carcinoma progression
por: Li, Ying‐Qing, et al.
Publicado: (2020)

Toxoplasma gondii Clp family protein: TgClpB1 plays a crucial role in thermotolerance
por: Cao, Shinuo, et al.
Publicado: (2017)

Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease
por: Zuromski, Kristin L., et al.
Publicado: (2020)

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
por: Guo, Chenxi, et al.
Publicado: (2023)

ClpXP and ClpAP proteolytic activity on divisome substrates is differentially regulated following the Caulobacter asymmetric cell division
por: Williams, Brandon, et al.
Publicado: (2014)

The Protein Chaperone ClpX Targets Native and Non-native Aggregated Substrates for Remodeling, Disassembly, and Degradation with ClpP
por: LaBreck, Christopher J., et al.
Publicado: (2017)

The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development
por: Wood, Nicholas A., et al.
Publicado: (2020)

The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci
por: Pan, Stefan, et al.
Publicado: (2019)

Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis
por: Fujikado, Noriyuki, et al.
Publicado: (2006)

Substrate Discrimination by ClpB and Hsp104
por: Johnston, Danielle M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k9dfmi6v1allcmvrc501jp2ahp