Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma

Immune checkpoint inhibitors have changed the landscape of classic cancer treatment. However, their use is associated with the emergence of new adverse events. An elderly man with rheumatoid arthritis was started on pembrolizumab for newly diagnosed advanced lung cancer. He subsequently developed he...

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Autores principales: Akagi, Yu, Awano, Nobuyasu, Inomata, Minoru, Kuse, Naoyuki, Tone, Mari, Yoshimura, Hanako, Jo, Tatsunori, Takada, Kohei, Kumasaka, Toshio, Izumo, Takehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205536/
https://www.ncbi.nlm.nih.gov/pubmed/32009093
http://dx.doi.org/10.2169/internalmedicine.3889-19
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author Akagi, Yu
Awano, Nobuyasu
Inomata, Minoru
Kuse, Naoyuki
Tone, Mari
Yoshimura, Hanako
Jo, Tatsunori
Takada, Kohei
Kumasaka, Toshio
Izumo, Takehiro
author_facet Akagi, Yu
Awano, Nobuyasu
Inomata, Minoru
Kuse, Naoyuki
Tone, Mari
Yoshimura, Hanako
Jo, Tatsunori
Takada, Kohei
Kumasaka, Toshio
Izumo, Takehiro
author_sort Akagi, Yu
collection PubMed
description Immune checkpoint inhibitors have changed the landscape of classic cancer treatment. However, their use is associated with the emergence of new adverse events. An elderly man with rheumatoid arthritis was started on pembrolizumab for newly diagnosed advanced lung cancer. He subsequently developed hemophagocytic lymphohistiocytosis (HLH), which is potentially fatal but has not been properly established as an immune checkpoint inhibition-induced event. We herein report the case of a patient with pembrolizumab-induced HLH.
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spelling pubmed-72055362020-05-12 Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma Akagi, Yu Awano, Nobuyasu Inomata, Minoru Kuse, Naoyuki Tone, Mari Yoshimura, Hanako Jo, Tatsunori Takada, Kohei Kumasaka, Toshio Izumo, Takehiro Intern Med Case Report Immune checkpoint inhibitors have changed the landscape of classic cancer treatment. However, their use is associated with the emergence of new adverse events. An elderly man with rheumatoid arthritis was started on pembrolizumab for newly diagnosed advanced lung cancer. He subsequently developed hemophagocytic lymphohistiocytosis (HLH), which is potentially fatal but has not been properly established as an immune checkpoint inhibition-induced event. We herein report the case of a patient with pembrolizumab-induced HLH. The Japanese Society of Internal Medicine 2020-02-01 2020-04-15 /pmc/articles/PMC7205536/ /pubmed/32009093 http://dx.doi.org/10.2169/internalmedicine.3889-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Akagi, Yu
Awano, Nobuyasu
Inomata, Minoru
Kuse, Naoyuki
Tone, Mari
Yoshimura, Hanako
Jo, Tatsunori
Takada, Kohei
Kumasaka, Toshio
Izumo, Takehiro
Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma
title Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma
title_full Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma
title_fullStr Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma
title_full_unstemmed Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma
title_short Hemophagocytic Lymphohistiocytosis in a Patient with Rheumatoid Arthritis on Pembrolizumab for Lung Adenocarcinoma
title_sort hemophagocytic lymphohistiocytosis in a patient with rheumatoid arthritis on pembrolizumab for lung adenocarcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205536/
https://www.ncbi.nlm.nih.gov/pubmed/32009093
http://dx.doi.org/10.2169/internalmedicine.3889-19
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