Cargando…
Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological exami...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205540/ https://www.ncbi.nlm.nih.gov/pubmed/31875639 http://dx.doi.org/10.2169/internalmedicine.4072-19 |
_version_ | 1783530258707775488 |
---|---|
author | Sawada, Kenji Takai, Atsushi Yamada, Tomoyo Araki, Osamu Yamauchi, Yuki Eso, Yuji Takahashi, Ken Shindo, Takero Sakurai, Takaki Ueda, Yoshihide Seno, Hiroshi |
author_facet | Sawada, Kenji Takai, Atsushi Yamada, Tomoyo Araki, Osamu Yamauchi, Yuki Eso, Yuji Takahashi, Ken Shindo, Takero Sakurai, Takaki Ueda, Yoshihide Seno, Hiroshi |
author_sort | Sawada, Kenji |
collection | PubMed |
description | Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis. |
format | Online Article Text |
id | pubmed-7205540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-72055402020-05-12 Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis Sawada, Kenji Takai, Atsushi Yamada, Tomoyo Araki, Osamu Yamauchi, Yuki Eso, Yuji Takahashi, Ken Shindo, Takero Sakurai, Takaki Ueda, Yoshihide Seno, Hiroshi Intern Med Case Report Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis. The Japanese Society of Internal Medicine 2019-12-26 2020-04-15 /pmc/articles/PMC7205540/ /pubmed/31875639 http://dx.doi.org/10.2169/internalmedicine.4072-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Sawada, Kenji Takai, Atsushi Yamada, Tomoyo Araki, Osamu Yamauchi, Yuki Eso, Yuji Takahashi, Ken Shindo, Takero Sakurai, Takaki Ueda, Yoshihide Seno, Hiroshi Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis |
title | Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis |
title_full | Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis |
title_fullStr | Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis |
title_full_unstemmed | Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis |
title_short | Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis |
title_sort | hepatitis-associated aplastic anemia with rapid progression of liver fibrosis due to repeated hepatitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205540/ https://www.ncbi.nlm.nih.gov/pubmed/31875639 http://dx.doi.org/10.2169/internalmedicine.4072-19 |
work_keys_str_mv | AT sawadakenji hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT takaiatsushi hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT yamadatomoyo hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT arakiosamu hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT yamauchiyuki hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT esoyuji hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT takahashiken hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT shindotakero hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT sakuraitakaki hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT uedayoshihide hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis AT senohiroshi hepatitisassociatedaplasticanemiawithrapidprogressionofliverfibrosisduetorepeatedhepatitis |