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Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis

Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological exami...

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Autores principales: Sawada, Kenji, Takai, Atsushi, Yamada, Tomoyo, Araki, Osamu, Yamauchi, Yuki, Eso, Yuji, Takahashi, Ken, Shindo, Takero, Sakurai, Takaki, Ueda, Yoshihide, Seno, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205540/
https://www.ncbi.nlm.nih.gov/pubmed/31875639
http://dx.doi.org/10.2169/internalmedicine.4072-19
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author Sawada, Kenji
Takai, Atsushi
Yamada, Tomoyo
Araki, Osamu
Yamauchi, Yuki
Eso, Yuji
Takahashi, Ken
Shindo, Takero
Sakurai, Takaki
Ueda, Yoshihide
Seno, Hiroshi
author_facet Sawada, Kenji
Takai, Atsushi
Yamada, Tomoyo
Araki, Osamu
Yamauchi, Yuki
Eso, Yuji
Takahashi, Ken
Shindo, Takero
Sakurai, Takaki
Ueda, Yoshihide
Seno, Hiroshi
author_sort Sawada, Kenji
collection PubMed
description Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis.
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spelling pubmed-72055402020-05-12 Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis Sawada, Kenji Takai, Atsushi Yamada, Tomoyo Araki, Osamu Yamauchi, Yuki Eso, Yuji Takahashi, Ken Shindo, Takero Sakurai, Takaki Ueda, Yoshihide Seno, Hiroshi Intern Med Case Report Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis. The Japanese Society of Internal Medicine 2019-12-26 2020-04-15 /pmc/articles/PMC7205540/ /pubmed/31875639 http://dx.doi.org/10.2169/internalmedicine.4072-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sawada, Kenji
Takai, Atsushi
Yamada, Tomoyo
Araki, Osamu
Yamauchi, Yuki
Eso, Yuji
Takahashi, Ken
Shindo, Takero
Sakurai, Takaki
Ueda, Yoshihide
Seno, Hiroshi
Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
title Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
title_full Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
title_fullStr Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
title_full_unstemmed Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
title_short Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis
title_sort hepatitis-associated aplastic anemia with rapid progression of liver fibrosis due to repeated hepatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205540/
https://www.ncbi.nlm.nih.gov/pubmed/31875639
http://dx.doi.org/10.2169/internalmedicine.4072-19
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