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Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()

INTRODUCTION: SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and...

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Autores principales: Serrano-Castro, P.J., Estivill-Torrús, G., Cabezudo-García, P., Reyes-Bueno, J.A., Ciano Petersen, N., Aguilar-Castillo, M.J., Suárez-Pérez, J., Jiménez-Hernández, M.D., Moya-Molina, M.Á., Oliver-Martos, B., Arrabal-Gómez, C., Rodríguez de Fonseca, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Neurología. Published by Elsevier España, S.L.U. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205729/
http://dx.doi.org/10.1016/j.nrleng.2020.04.002
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author Serrano-Castro, P.J.
Estivill-Torrús, G.
Cabezudo-García, P.
Reyes-Bueno, J.A.
Ciano Petersen, N.
Aguilar-Castillo, M.J.
Suárez-Pérez, J.
Jiménez-Hernández, M.D.
Moya-Molina, M.Á.
Oliver-Martos, B.
Arrabal-Gómez, C.
Rodríguez de Fonseca, F.
author_facet Serrano-Castro, P.J.
Estivill-Torrús, G.
Cabezudo-García, P.
Reyes-Bueno, J.A.
Ciano Petersen, N.
Aguilar-Castillo, M.J.
Suárez-Pérez, J.
Jiménez-Hernández, M.D.
Moya-Molina, M.Á.
Oliver-Martos, B.
Arrabal-Gómez, C.
Rodríguez de Fonseca, F.
author_sort Serrano-Castro, P.J.
collection PubMed
description INTRODUCTION: SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. DEVELOPMENT: We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. CONCLUSIONS: SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors.
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spelling pubmed-72057292020-05-08 Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?() Serrano-Castro, P.J. Estivill-Torrús, G. Cabezudo-García, P. Reyes-Bueno, J.A. Ciano Petersen, N. Aguilar-Castillo, M.J. Suárez-Pérez, J. Jiménez-Hernández, M.D. Moya-Molina, M.Á. Oliver-Martos, B. Arrabal-Gómez, C. Rodríguez de Fonseca, F. Neurología (English Edition) Review Article INTRODUCTION: SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. DEVELOPMENT: We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. CONCLUSIONS: SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors. Sociedad Española de Neurología. Published by Elsevier España, S.L.U. 2020-05 2020-05-08 /pmc/articles/PMC7205729/ http://dx.doi.org/10.1016/j.nrleng.2020.04.002 Text en © 2020 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Serrano-Castro, P.J.
Estivill-Torrús, G.
Cabezudo-García, P.
Reyes-Bueno, J.A.
Ciano Petersen, N.
Aguilar-Castillo, M.J.
Suárez-Pérez, J.
Jiménez-Hernández, M.D.
Moya-Molina, M.Á.
Oliver-Martos, B.
Arrabal-Gómez, C.
Rodríguez de Fonseca, F.
Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()
title Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()
title_full Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()
title_fullStr Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()
title_full_unstemmed Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()
title_short Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?()
title_sort impact of sars-cov-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?()
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205729/
http://dx.doi.org/10.1016/j.nrleng.2020.04.002
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