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Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats
We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI‐induced heart failure. Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S‐MI); aerobic exercised...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205792/ https://www.ncbi.nlm.nih.gov/pubmed/32239667 http://dx.doi.org/10.1111/jcmm.15191 |
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author | Gomes, Mariana J. Pagan, Luana U. Lima, Aline R. R. Reyes, David R. A. Martinez, Paula F. Damatto, Felipe C. Pontes, Thierres H. D. Rodrigues, Eder A. Souza, Lidiane M. Tosta, Ingrid F. Fernandes, Ana A. H. Zornoff, Leonardo A. M. Okoshi, Katashi Okoshi, Marina P. |
author_facet | Gomes, Mariana J. Pagan, Luana U. Lima, Aline R. R. Reyes, David R. A. Martinez, Paula F. Damatto, Felipe C. Pontes, Thierres H. D. Rodrigues, Eder A. Souza, Lidiane M. Tosta, Ingrid F. Fernandes, Ana A. H. Zornoff, Leonardo A. M. Okoshi, Katashi Okoshi, Marina P. |
author_sort | Gomes, Mariana J. |
collection | PubMed |
description | We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI‐induced heart failure. Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S‐MI); aerobic exercised MI (A‐MI); and resistance exercised MI (R‐MI). Exercised rats trained three times a week for 12 weeks on a treadmill or ladder. Statistical analysis was performed by ANOVA or Kruskal‐Wallis test. Functional aerobic capacity was greater in A‐MI and strength gain higher in R‐MI. Echocardiographic parameters did not differ between infarct groups. Reactive oxygen species production, evaluated by fluorescence, was higher in S‐MI than Sham, and lipid hydroperoxide concentration was lower in A‐MI than the other groups. Glutathione peroxidase activity was higher in A‐MI than S‐MI and R‐MI. Superoxide dismutase was lower in S‐MI than Sham and R‐MI. Gastrocnemius cross‐sectional area, satellite cell activation and expression of the ubiquitin‐proteasome system proteins did not differ between groups. In conclusion, aerobic exercise and resistance exercise improve functional capacity and maximum load carrying, respectively, without changing cardiac remodelling in infarcted rats. In the gastrocnemius, infarction increases oxidative stress and changes antioxidant enzyme activities. Aerobic exercise reduces oxidative stress and attenuates superoxide dismutase and glutathione peroxidase changes. |
format | Online Article Text |
id | pubmed-7205792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72057922020-05-11 Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats Gomes, Mariana J. Pagan, Luana U. Lima, Aline R. R. Reyes, David R. A. Martinez, Paula F. Damatto, Felipe C. Pontes, Thierres H. D. Rodrigues, Eder A. Souza, Lidiane M. Tosta, Ingrid F. Fernandes, Ana A. H. Zornoff, Leonardo A. M. Okoshi, Katashi Okoshi, Marina P. J Cell Mol Med Original Articles We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI‐induced heart failure. Three months after MI induction, Wistar rats were divided into four groups: Sham; sedentary MI (S‐MI); aerobic exercised MI (A‐MI); and resistance exercised MI (R‐MI). Exercised rats trained three times a week for 12 weeks on a treadmill or ladder. Statistical analysis was performed by ANOVA or Kruskal‐Wallis test. Functional aerobic capacity was greater in A‐MI and strength gain higher in R‐MI. Echocardiographic parameters did not differ between infarct groups. Reactive oxygen species production, evaluated by fluorescence, was higher in S‐MI than Sham, and lipid hydroperoxide concentration was lower in A‐MI than the other groups. Glutathione peroxidase activity was higher in A‐MI than S‐MI and R‐MI. Superoxide dismutase was lower in S‐MI than Sham and R‐MI. Gastrocnemius cross‐sectional area, satellite cell activation and expression of the ubiquitin‐proteasome system proteins did not differ between groups. In conclusion, aerobic exercise and resistance exercise improve functional capacity and maximum load carrying, respectively, without changing cardiac remodelling in infarcted rats. In the gastrocnemius, infarction increases oxidative stress and changes antioxidant enzyme activities. Aerobic exercise reduces oxidative stress and attenuates superoxide dismutase and glutathione peroxidase changes. John Wiley and Sons Inc. 2020-04-02 2020-05 /pmc/articles/PMC7205792/ /pubmed/32239667 http://dx.doi.org/10.1111/jcmm.15191 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Gomes, Mariana J. Pagan, Luana U. Lima, Aline R. R. Reyes, David R. A. Martinez, Paula F. Damatto, Felipe C. Pontes, Thierres H. D. Rodrigues, Eder A. Souza, Lidiane M. Tosta, Ingrid F. Fernandes, Ana A. H. Zornoff, Leonardo A. M. Okoshi, Katashi Okoshi, Marina P. Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
title | Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
title_full | Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
title_fullStr | Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
title_full_unstemmed | Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
title_short | Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
title_sort | effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205792/ https://www.ncbi.nlm.nih.gov/pubmed/32239667 http://dx.doi.org/10.1111/jcmm.15191 |
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