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Mitochondrial biogenesis: An update
In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing. Recently, considerable progress has been made...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205802/ https://www.ncbi.nlm.nih.gov/pubmed/32279443 http://dx.doi.org/10.1111/jcmm.15194 |
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author | Popov, Lucia‐Doina |
author_facet | Popov, Lucia‐Doina |
author_sort | Popov, Lucia‐Doina |
collection | PubMed |
description | In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing. Recently, considerable progress has been made in deciphering mitochondrial biogenesis‐related proteins and genes that function in health and in pathology‐related circumstances. However, an outlook on the intracellular mechanisms shared by the main players that drive mitochondrial biogenesis machinery is still missing. Here, we provide such a view by focusing on the following issues: (a) the role of mitochondrial biogenesis in homeostasis of the mitochondrial mass and function, (b) the signalling pathways beyond the induction/promotion, stimulation and inhibition of mitochondrial biogenesis and (c) the therapeutic applications aiming the repair and regeneration of defective mitochondrial biogenesis (in ageing, metabolic diseases, neurodegeneration and cancer). The review is concluded by the perspectives of mitochondrial medicine and research. |
format | Online Article Text |
id | pubmed-7205802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72058022020-05-11 Mitochondrial biogenesis: An update Popov, Lucia‐Doina J Cell Mol Med Reviews In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing. Recently, considerable progress has been made in deciphering mitochondrial biogenesis‐related proteins and genes that function in health and in pathology‐related circumstances. However, an outlook on the intracellular mechanisms shared by the main players that drive mitochondrial biogenesis machinery is still missing. Here, we provide such a view by focusing on the following issues: (a) the role of mitochondrial biogenesis in homeostasis of the mitochondrial mass and function, (b) the signalling pathways beyond the induction/promotion, stimulation and inhibition of mitochondrial biogenesis and (c) the therapeutic applications aiming the repair and regeneration of defective mitochondrial biogenesis (in ageing, metabolic diseases, neurodegeneration and cancer). The review is concluded by the perspectives of mitochondrial medicine and research. John Wiley and Sons Inc. 2020-04-12 2020-05 /pmc/articles/PMC7205802/ /pubmed/32279443 http://dx.doi.org/10.1111/jcmm.15194 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Popov, Lucia‐Doina Mitochondrial biogenesis: An update |
title | Mitochondrial biogenesis: An update |
title_full | Mitochondrial biogenesis: An update |
title_fullStr | Mitochondrial biogenesis: An update |
title_full_unstemmed | Mitochondrial biogenesis: An update |
title_short | Mitochondrial biogenesis: An update |
title_sort | mitochondrial biogenesis: an update |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205802/ https://www.ncbi.nlm.nih.gov/pubmed/32279443 http://dx.doi.org/10.1111/jcmm.15194 |
work_keys_str_mv | AT popovluciadoina mitochondrialbiogenesisanupdate |