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Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis

Increasing findings suggest the critical role of circular RNA (circRNA) in human cancer, and chemotherapy resistance is a poor prognostic factor for hepatocellular carcinoma (HCC). The function of circRNA in the HCC oxaliplatin (OXA) resistance remains largely unknown. In this study, we found that c...

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Autores principales: Li, Jin, Qin, Xiaoping, Wu, Ruishan, Wan, Li, Zhang, Liang, Liu, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205830/
https://www.ncbi.nlm.nih.gov/pubmed/32222024
http://dx.doi.org/10.1111/jcmm.15162
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author Li, Jin
Qin, Xiaoping
Wu, Ruishan
Wan, Li
Zhang, Liang
Liu, Rui
author_facet Li, Jin
Qin, Xiaoping
Wu, Ruishan
Wan, Li
Zhang, Liang
Liu, Rui
author_sort Li, Jin
collection PubMed
description Increasing findings suggest the critical role of circular RNA (circRNA) in human cancer, and chemotherapy resistance is a poor prognostic factor for hepatocellular carcinoma (HCC). The function of circRNA in the HCC oxaliplatin (OXA) resistance remains largely unknown. In this study, we found that circRNA circFBXO11 was significantly up‐regulated in HCC tissues, and the circFBXO11 overexpression was associated with poor prognosis. CircFBXO11 was found to promote the HCC proliferation, cycle progress and OXA resistance. Mechanistically, circFBXO11 was predominantly localized in the cytoplasm and harboured the miR‐605, thereby targeting FOXO3 protein. Furthermore, FOXO3 targeted the promoter region of ABCB1 to accelerate its expression. In conclusion, this research reveals the role of circFBXO11/miR‐605/FOXO3/ABCB1 axis in the HCC OXA resistance, providing new insight for circRNA‐based diagnostic and therapeutic strategies.
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spelling pubmed-72058302020-05-11 Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis Li, Jin Qin, Xiaoping Wu, Ruishan Wan, Li Zhang, Liang Liu, Rui J Cell Mol Med Original Articles Increasing findings suggest the critical role of circular RNA (circRNA) in human cancer, and chemotherapy resistance is a poor prognostic factor for hepatocellular carcinoma (HCC). The function of circRNA in the HCC oxaliplatin (OXA) resistance remains largely unknown. In this study, we found that circRNA circFBXO11 was significantly up‐regulated in HCC tissues, and the circFBXO11 overexpression was associated with poor prognosis. CircFBXO11 was found to promote the HCC proliferation, cycle progress and OXA resistance. Mechanistically, circFBXO11 was predominantly localized in the cytoplasm and harboured the miR‐605, thereby targeting FOXO3 protein. Furthermore, FOXO3 targeted the promoter region of ABCB1 to accelerate its expression. In conclusion, this research reveals the role of circFBXO11/miR‐605/FOXO3/ABCB1 axis in the HCC OXA resistance, providing new insight for circRNA‐based diagnostic and therapeutic strategies. John Wiley and Sons Inc. 2020-03-28 2020-05 /pmc/articles/PMC7205830/ /pubmed/32222024 http://dx.doi.org/10.1111/jcmm.15162 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Li, Jin
Qin, Xiaoping
Wu, Ruishan
Wan, Li
Zhang, Liang
Liu, Rui
Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
title Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
title_full Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
title_fullStr Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
title_full_unstemmed Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
title_short Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR‐605/FOXO3/ABCB1 axis
title_sort circular rna circfbxo11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through mir‐605/foxo3/abcb1 axis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205830/
https://www.ncbi.nlm.nih.gov/pubmed/32222024
http://dx.doi.org/10.1111/jcmm.15162
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