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One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project

Mediterranean diet has been proposed to promote healthy aging, but its effects on aging biomarkers have been poorly investigated. We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measu...

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Autores principales: Gensous, Noémie, Garagnani, Paolo, Santoro, Aurelia, Giuliani, Cristina, Ostan, Rita, Fabbri, Cristina, Milazzo, Maddalena, Gentilini, Davide, di Blasio, Anna Maria, Pietruszka, Barbara, Madej, Dawid, Bialecka-Debek, Agata, Brzozowska, Anna, Franceschi, Claudio, Bacalini, Maria Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205853/
https://www.ncbi.nlm.nih.gov/pubmed/31981007
http://dx.doi.org/10.1007/s11357-019-00149-0
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author Gensous, Noémie
Garagnani, Paolo
Santoro, Aurelia
Giuliani, Cristina
Ostan, Rita
Fabbri, Cristina
Milazzo, Maddalena
Gentilini, Davide
di Blasio, Anna Maria
Pietruszka, Barbara
Madej, Dawid
Bialecka-Debek, Agata
Brzozowska, Anna
Franceschi, Claudio
Bacalini, Maria Giulia
author_facet Gensous, Noémie
Garagnani, Paolo
Santoro, Aurelia
Giuliani, Cristina
Ostan, Rita
Fabbri, Cristina
Milazzo, Maddalena
Gentilini, Davide
di Blasio, Anna Maria
Pietruszka, Barbara
Madej, Dawid
Bialecka-Debek, Agata
Brzozowska, Anna
Franceschi, Claudio
Bacalini, Maria Giulia
author_sort Gensous, Noémie
collection PubMed
description Mediterranean diet has been proposed to promote healthy aging, but its effects on aging biomarkers have been poorly investigated. We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath’s clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention. The effect was statistically significant in the group of Polish females and in subjects who were epigenetically older at baseline. A genome-wide association study of epigenetic age changes after the intervention did not return significant (adjusted p value < 0.05) loci. However, we identified small-effect alleles (nominal p value < 10–4), mapping in genes enriched in pathways related to energy metabolism, regulation of cell cycle, and of immune functions. Together, these findings suggest that Mediterranean diet can promote epigenetic rejuvenation but with country-, sex-, and individual-specific effects, thus highlighting the need for a personalized approach to nutritional interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11357-019-00149-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-72058532020-05-12 One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project Gensous, Noémie Garagnani, Paolo Santoro, Aurelia Giuliani, Cristina Ostan, Rita Fabbri, Cristina Milazzo, Maddalena Gentilini, Davide di Blasio, Anna Maria Pietruszka, Barbara Madej, Dawid Bialecka-Debek, Agata Brzozowska, Anna Franceschi, Claudio Bacalini, Maria Giulia GeroScience Original Article Mediterranean diet has been proposed to promote healthy aging, but its effects on aging biomarkers have been poorly investigated. We evaluated the impact of a 1-year Mediterranean-like diet in a pilot study including 120 elderly healthy subjects from the NU-AGE study (60 Italians, 60 Poles) by measuring the changes in their epigenetic age, assessed by Horvath’s clock. We observed a trend towards epigenetic rejuvenation of participants after nutritional intervention. The effect was statistically significant in the group of Polish females and in subjects who were epigenetically older at baseline. A genome-wide association study of epigenetic age changes after the intervention did not return significant (adjusted p value < 0.05) loci. However, we identified small-effect alleles (nominal p value < 10–4), mapping in genes enriched in pathways related to energy metabolism, regulation of cell cycle, and of immune functions. Together, these findings suggest that Mediterranean diet can promote epigenetic rejuvenation but with country-, sex-, and individual-specific effects, thus highlighting the need for a personalized approach to nutritional interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11357-019-00149-0) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-01-24 /pmc/articles/PMC7205853/ /pubmed/31981007 http://dx.doi.org/10.1007/s11357-019-00149-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Gensous, Noémie
Garagnani, Paolo
Santoro, Aurelia
Giuliani, Cristina
Ostan, Rita
Fabbri, Cristina
Milazzo, Maddalena
Gentilini, Davide
di Blasio, Anna Maria
Pietruszka, Barbara
Madej, Dawid
Bialecka-Debek, Agata
Brzozowska, Anna
Franceschi, Claudio
Bacalini, Maria Giulia
One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
title One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
title_full One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
title_fullStr One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
title_full_unstemmed One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
title_short One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project
title_sort one-year mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the nu-age project
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205853/
https://www.ncbi.nlm.nih.gov/pubmed/31981007
http://dx.doi.org/10.1007/s11357-019-00149-0
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