RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase

End resection of DNA double-strand breaks (DSBs) to form 3′ single-strand DNA (ssDNA) is critical to initiate the homologous recombination (HR) pathway of DSB repair. HR pathway is strictly limited in the G1-phase cells because of lack of homologous DNA as the templates. Exonuclease 1 (EXO1) is the...

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Detalles Bibliográficos
Autores principales: Xie, Ying, Liu, Yi-Ke, Guo, Zong-Pei, Guan, Hua, Liu, Xiao-Dan, Xie, Da-Fei, Jiang, Yi-Guo, Ma, Teng, Zhou, Ping-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205894/
https://www.ncbi.nlm.nih.gov/pubmed/31562368
http://dx.doi.org/10.1038/s41418-019-0424-4

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