REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway

Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC dedifferentiation are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator high...

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Detalles Bibliográficos
Autores principales: Jiao, Chan, Li, Lin, Zhang, Pei, Zhang, Li, Li, Ke, Fang, Riqun, Yuan, Lei, Shi, Kaixuan, Pan, Linan, Guo, Qiannan, Gao, Xiao, Chen, Geng, Xu, Shichen, Wang, Qingwei, Zuo, Di, Wu, Wei, Qiao, Shanlou, Wang, Xiaoshuang, Moses, Robb, Xiao, Jianru, Li, Lei, Dang, Yongyan, Li, Xiaotao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205985/
https://www.ncbi.nlm.nih.gov/pubmed/31243343
http://dx.doi.org/10.1038/s41418-019-0367-9

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