SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation

Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity. However, the underlying mechanism linking the two pathways remains elusive. Here, we show...

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Detalles Bibliográficos
Autores principales: Zhang, Wenyu, Feng, Yanling, Guo, Qiqiang, Guo, Wendong, Xu, Hongde, Li, Xiaoman, Yi, Fei, Guan, Yi, Geng, Nanxi, Wang, Pingyuan, Cao, Longyue, O’Rourke, Brian P., Jo, Juhyeon, Kwon, Jiyun, Wang, Ruihong, Song, Xiaoyu, Lee, In Hye, Cao, Liu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206007/
https://www.ncbi.nlm.nih.gov/pubmed/31209362
http://dx.doi.org/10.1038/s41418-019-0369-7

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