Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells

Vitamin K2 has been shown to exert remarkable anticancer activity. However, the detailed mechanism remains unclear. Here, our study was the first to show that Vitamin K2 significantly promoted the glycolysis in bladder cancer cells by upregulating glucose consumption and lactate production, whereas...

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Detalles Bibliográficos
Autores principales: Duan, Fengsen, Mei, Chunlei, Yang, Luhao, Zheng, Junyan, Lu, Huiai, Xia, Yanzhi, Hsu, Stacy, Liang, Huageng, Hong, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206016/
https://www.ncbi.nlm.nih.gov/pubmed/32382009
http://dx.doi.org/10.1038/s41598-020-64880-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206016/
https://www.ncbi.nlm.nih.gov/pubmed/32382009
http://dx.doi.org/10.1038/s41598-020-64880-x

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