Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling

Microtubule-targeting agents (MTAs) are a class of most widely used chemotherapeutics and their mechanism of action has long been assumed to be mitotic arrest of rapidly dividing tumor cells. In contrast to such notion, here we show—in many cancer cell types—MTAs function by triggering membrane TNF...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Yang, Yu, Zhou, Shen’ao, He, Xueyan, Cao, Xuan, Wu, Chenlu, Hu, Hong, Qin, Jie, Wei, Gang, Wang, Huayi, Liu, Suling, Sun, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206059/
https://www.ncbi.nlm.nih.gov/pubmed/31645676
http://dx.doi.org/10.1038/s41418-019-0441-3

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