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FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing 5 (FNDC5) and its cleaved form, irisin, could preserve mitochondrial function and attenuate oxidative damage as well as...

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Detalles Bibliográficos
Autores principales:	Zhang, Xin, Hu, Can, Kong, Chun-Yan, Song, Peng, Wu, Hai-Ming, Xu, Si-Chi, Yuan, Yu-Pei, Deng, Wei, Ma, Zhen-Guo, Tang, Qi-Zhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206111/ https://www.ncbi.nlm.nih.gov/pubmed/31209361 http://dx.doi.org/10.1038/s41418-019-0372-z

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