Liver stage malaria infection is controlled by host regulators of lipid peroxidation

The facets of host control during Plasmodium liver infection remain largely unknown. We find that the SLC7a11-GPX4 pathway, which has been associated with the production of reactive oxygen species, lipid peroxidation, and a form of cell death called ferroptosis, plays a critical role in control of P...

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Detalles Bibliográficos
Autores principales: Kain, Heather S., Glennon, Elizabeth K. K., Vijayan, Kamalakannan, Arang, Nadia, Douglass, Alyse N., Fortin, Chelsea L., Zuck, Meghan, Lewis, Adam J., Whiteside, Samantha L., Dudgeon, Denali R., Johnson, Jarrod S., Aderem, Alan, Stevens, Kelly R., Kaushansky, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206113/
https://www.ncbi.nlm.nih.gov/pubmed/31065106
http://dx.doi.org/10.1038/s41418-019-0338-1

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