Cargando…

Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

BACKGROUND: The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders. METHODS: This study investigated the roles of TGR5 activation in attenuating BBB damage and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Hui, Matei, Nate, McBride, Devin W., Xu, Yang, Tang, Jiping, Luo, Benyan, Zhang, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206796/ https://www.ncbi.nlm.nih.gov/pubmed/32381096 http://dx.doi.org/10.1186/s12929-020-00656-9

Ejemplares similares

Correction to: Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats
por: Liang, Hui, et al.
Publicado: (2020)

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats
por: Liang, Hui, et al.
Publicado: (2021)

N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway
por: Fusco, Roberta, et al.
Publicado: (2019)

The Efficacy of Hyperbaric Oxygen Therapy on Middle Cerebral Artery Occlusion in Animal Studies: A Meta-Analysis
por: Xu, Yang, et al.
Publicado: (2016)

Sieve element occlusion provides resistance against Aphis gossypii in TGR‐1551 melons
por: Peng, Hsuan‐Chieh, et al.
Publicado: (2018)

TGR5 deficiency aggravates hepatic ischemic/reperfusion injury via inhibiting SIRT3/FOXO3/HIF-1ɑ pathway
por: Wang, Qi, et al.
Publicado: (2020)

Protective Effects of Nuciferine in Middle Cerebral Artery Occlusion Rats Based on Transcriptomics
por: Chen, Chang, et al.
Publicado: (2022)

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
por: Minten, Elizabeth V., et al.
Publicado: (2021)

Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats
por: Wu, Huihui, et al.
Publicado: (2020)

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2011)

Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion
por: Liu, Yanqun, et al.
Publicado: (2014)

Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction
por: Zhang, Weijin, et al.
Publicado: (2017)

TgrC1 Has Distinct Functions in Dictyostelium Development and Allorecognition
por: Wang, Yue, et al.
Publicado: (2015)

Early Thrombectomy Protects the Internal Capsule in Patients With Proximal Middle Cerebral Artery Occlusion
por: Kaesmacher, Johannes, et al.
Publicado: (2021)

Mouse Model of Middle Cerebral Artery Occlusion
por: Chiang, Terrance, et al.
Publicado: (2011)

Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
por: Liu, Zhenquan, et al.
Publicado: (2010)

Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2013)

Silencing of lncRNA XLOC_035088 Protects Middle Cerebral Artery Occlusion-Induced Ischemic Stroke by Notch1 Signaling
por: Chen, Miao, et al.
Publicado: (2020)

An Experimental Model of Vasovagal Syncope Induces Cerebral Hypoperfusion and Fainting-Like Behavior in Awake Rats
por: McBride, Devin W., et al.
Publicado: (2016)

Cerebral Infarction Due to Occlusion of Main Trunk of Middle Cerebral Artery in Patient with Accessory Middle Cerebral Artery
por: Tsuchiya, Atsushi, et al.
Publicado: (2022)

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
por: Harach, Taoufiq, et al.
Publicado: (2012)

Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats
por: Wang, Ai-Hong, et al.
Publicado: (2018)

TGR5, Not Only a Metabolic Regulator
por: Guo, Cong, et al.
Publicado: (2016)

TGR5 Signaling in Hepatic Metabolic Health
por: Holter, Marlena M., et al.
Publicado: (2020)

Middle cerebral artery branch occlusion mimicking an aneurysm
por: Takeuchi, Satoru, et al.
Publicado: (2015)

A case of cerebral hyperperfusion following spontaneous recanalization of occluded middle cerebral artery: Reperfusion injury or true cerebral hyperperfusion syndrome?
por: Xu, Ziqi, et al.
Publicado: (2017)

TGR5 Activation Ameliorates Mitochondrial Homeostasis via Regulating the PKCδ/Drp1-HK2 Signaling in Diabetic Retinopathy
por: Zhang, Meng-Yuan, et al.
Publicado: (2022)

BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1
por: Zhang, Wenwen, et al.
Publicado: (2016)

Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α(1)‐Adrenoceptor–Protein Kinase Cε–Endothelial NO Synthase Pathway in Rats
por: McBride, Devin W., et al.
Publicado: (2018)

Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion
por: Alimohamadi, Raheleh, et al.
Publicado: (2019)

Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion
por: Arroja, M. M. C., et al.
Publicado: (2019)

Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration
por: Keitel, Verena, et al.
Publicado: (2014)

Incidence of Hypersensitivity Reactions to Carboplatin or Paclitaxel in Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer With or Without BRCA1 or BRCA2 Mutations
por: Garcia, Andrew, et al.
Publicado: (2019)

Electroacupuncture: a new approach to open the blood–brain barrier in rats recovering from middle cerebral artery occlusion
por: Zhang, Jiangsong, et al.
Publicado: (2018)

DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
por: Mamtilahun, Muyassar, et al.
Publicado: (2021)

Protocol for middle cerebral artery occlusion by an intraluminal suture method
por: Rupadevi, M., et al.
Publicado: (2011)

Late Spontaneous Recanalization of Chronic Middle Cerebral Artery Occlusion
por: Lee, Cheol-Young, et al.
Publicado: (2012)

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice
por: Koch, Konrad, et al.
Publicado: (2017)

TGR5 expression in normal kidney and renal neoplasms
por: Zhao, Chaohui Lisa, et al.
Publicado: (2018)

TGR5 regulates portal perfusion pressure of the liver
por: Ghallab, Ahmed
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kh50lm47c1tg46hk53b2l8t7fj