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Nanocurcumin: A Promising Candidate for Therapeutic Applications

Curcuma longa is an important medicinal plant and a spice in Asia. Curcumin (diferuloylmethane) is a hydrophobic bioactive ingredient found in a rhizome of the C. longa. It has drawn immense attention in recent years for its variety of biological and pharmacological action. However, its low water so...

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Autores principales: Karthikeyan, Adhimoolam, Senthil, Natesan, Min, Taesun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206872/
https://www.ncbi.nlm.nih.gov/pubmed/32425772
http://dx.doi.org/10.3389/fphar.2020.00487
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author Karthikeyan, Adhimoolam
Senthil, Natesan
Min, Taesun
author_facet Karthikeyan, Adhimoolam
Senthil, Natesan
Min, Taesun
author_sort Karthikeyan, Adhimoolam
collection PubMed
description Curcuma longa is an important medicinal plant and a spice in Asia. Curcumin (diferuloylmethane) is a hydrophobic bioactive ingredient found in a rhizome of the C. longa. It has drawn immense attention in recent years for its variety of biological and pharmacological action. However, its low water solubility, poor bioavailability, and rapid metabolism represent major drawbacks for its successful therapeutic applications. Hence, researchers have attempted to enhance the biological and pharmacological activity of curcumin and overcome its drawbacks by efficient delivery systems, particularly nanoencapsulation. Research efforts so far and data from the available literature have shown a satisfactory potential of nanorange formulations of curcumin (Nanocurcumin), it increases all the biological and pharmacological benefits of curcumin, which was not significantly possible earlier. For the synthesis of nanocurcumin, an array of techniques has been developed and each technique has its own advantages and individual characteristics. The two most popular and effective techniques are ionic gelation and antisolvent precipitation. So far, many curcumin nanoformulations have been developed to enhance curcumin delivery, thereby overcoming the low therapeutic effects. However, most of the nanoformulation of curcumin remained at the concept level evidence, thus, several questions and challenges still exist to recommend the nanocurcumin as a promising candidate for therapeutic applications. In this review, we discuss the different curcumin nanoformulation and nanocurcumin implications for different therapeutic applications as well as the status of ongoing clinical trials and patents. We also discuss the research gap and future research directions needed to propose curcumin as a promising therapeutic candidate.
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spelling pubmed-72068722020-05-18 Nanocurcumin: A Promising Candidate for Therapeutic Applications Karthikeyan, Adhimoolam Senthil, Natesan Min, Taesun Front Pharmacol Pharmacology Curcuma longa is an important medicinal plant and a spice in Asia. Curcumin (diferuloylmethane) is a hydrophobic bioactive ingredient found in a rhizome of the C. longa. It has drawn immense attention in recent years for its variety of biological and pharmacological action. However, its low water solubility, poor bioavailability, and rapid metabolism represent major drawbacks for its successful therapeutic applications. Hence, researchers have attempted to enhance the biological and pharmacological activity of curcumin and overcome its drawbacks by efficient delivery systems, particularly nanoencapsulation. Research efforts so far and data from the available literature have shown a satisfactory potential of nanorange formulations of curcumin (Nanocurcumin), it increases all the biological and pharmacological benefits of curcumin, which was not significantly possible earlier. For the synthesis of nanocurcumin, an array of techniques has been developed and each technique has its own advantages and individual characteristics. The two most popular and effective techniques are ionic gelation and antisolvent precipitation. So far, many curcumin nanoformulations have been developed to enhance curcumin delivery, thereby overcoming the low therapeutic effects. However, most of the nanoformulation of curcumin remained at the concept level evidence, thus, several questions and challenges still exist to recommend the nanocurcumin as a promising candidate for therapeutic applications. In this review, we discuss the different curcumin nanoformulation and nanocurcumin implications for different therapeutic applications as well as the status of ongoing clinical trials and patents. We also discuss the research gap and future research directions needed to propose curcumin as a promising therapeutic candidate. Frontiers Media S.A. 2020-05-01 /pmc/articles/PMC7206872/ /pubmed/32425772 http://dx.doi.org/10.3389/fphar.2020.00487 Text en Copyright © 2020 Karthikeyan, Senthil and Min http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Karthikeyan, Adhimoolam
Senthil, Natesan
Min, Taesun
Nanocurcumin: A Promising Candidate for Therapeutic Applications
title Nanocurcumin: A Promising Candidate for Therapeutic Applications
title_full Nanocurcumin: A Promising Candidate for Therapeutic Applications
title_fullStr Nanocurcumin: A Promising Candidate for Therapeutic Applications
title_full_unstemmed Nanocurcumin: A Promising Candidate for Therapeutic Applications
title_short Nanocurcumin: A Promising Candidate for Therapeutic Applications
title_sort nanocurcumin: a promising candidate for therapeutic applications
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206872/
https://www.ncbi.nlm.nih.gov/pubmed/32425772
http://dx.doi.org/10.3389/fphar.2020.00487
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