Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability

BACKGROUND: Microsatellite instability (MSI) occurs in 3% of urothelial carcinomas as a result of germline or somatic loss of function mutation in mismatch repair (MMR) proteins.1 Although MSH4 is a member of the DNA MMR mutS family, the association of MSH4 mutation with MSI has not been described....

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yuanquan, Jain, Rohit K, Glenn, Sean T, Xu, Bo, Singh, Prashant K, Wei, Lei, Hu, Qiang, Long, Mark, Hutson, Nicholas, Wang, Jianming, Battaglia, Sebastiano, George, Saby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206971/
https://www.ncbi.nlm.nih.gov/pubmed/32221012
http://dx.doi.org/10.1136/jitc-2019-000128

Ejemplares similares

Ejemplares similares