OR19-05 Steroid:Corticosteroid-Binding Globulin Interactions; Effects of Neutrophil Elastase Cleavage, Pyrexia and Acidosis

Context Corticosteroid-binding globulin (CBG) transports cortisol and other steroid hormones(1,2). High-affinity CBG (haCBG) undergoes proteolysis of the reactive centre loop (RCL) by neutrophil elastase (NE) at inflammatory sites, liberating immunomodulatory cortisol and altering conformation to lo...

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Detalles Bibliográficos
Autores principales: Meyer, Emily Jane, Torpy, David J, Chernykh, Anastasia, Thaysen-Anderson, Morten, Nenke, Marni Anne, Lewis, John, Rankin, Wayne, Polyak, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Adrenal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207580/
http://dx.doi.org/10.1210/jendso/bvaa046.109

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