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MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses

Renovascular hypertension (RVHT) is an important and potentially treatable form of resistant hypertension. Hypercortisolemia could also cause hypertension and diabetes mellitus. We experienced a case wherein adrenalectomy markedly improved blood pressure and plasma glucose levels in a patient with R...

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Autores principales: Higashitani, Takuya, Aono, Daisuke, Kometani, Mitsuhiro, Karashima, Shigehiro, Demura, Masashi, Yoneda, Takashi, Takeda, Yoshiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207581/
http://dx.doi.org/10.1210/jendso/bvaa046.2035
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author Higashitani, Takuya
Aono, Daisuke
Kometani, Mitsuhiro
Karashima, Shigehiro
Demura, Masashi
Yoneda, Takashi
Takeda, Yoshiyu
author_facet Higashitani, Takuya
Aono, Daisuke
Kometani, Mitsuhiro
Karashima, Shigehiro
Demura, Masashi
Yoneda, Takashi
Takeda, Yoshiyu
author_sort Higashitani, Takuya
collection PubMed
description Renovascular hypertension (RVHT) is an important and potentially treatable form of resistant hypertension. Hypercortisolemia could also cause hypertension and diabetes mellitus. We experienced a case wherein adrenalectomy markedly improved blood pressure and plasma glucose levels in a patient with RVHT and subclinical Cushing’s syndrome. A 62-year-old Japanese man had been treated for hypertension and diabetes mellitus for 10 years. He was hospitalized because of disturbance in consciousness. His blood pressure (BP) was 236/118 mmHg; pulse rate, 132 beats/min; and plasma glucose level, 712 mg/dl. Abdominal computed tomography scanning revealed the presence of bilateral adrenal masses and left atrophic kidney. Abdominal magnetic resonance angiography demonstrated marked stenosis of the left main renal artery. The patient was subsequently diagnosed with atherosclerotic RVHT with left renal artery stenosis. Bilateral adrenal masses were immunohistologically identified as potential sites for cortisol overproduction. Therefore, laparoscopic left nephrectomy and adrenalectomy were simultaneously performed resulting in improved BP and glucose levels. Pathological studies revealed the presence of multiple cortisol-producing adrenal nodules and aldosterone-producing cell clusters in the adjacent left adrenal cortex. In the present case, activated renin-angiotensin-aldosterone system and cortisol overproduction resulted in severe hypertension, which was managed with simultaneous unilateral nephrectomy and adrenalectomy.
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spelling pubmed-72075812020-05-13 MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses Higashitani, Takuya Aono, Daisuke Kometani, Mitsuhiro Karashima, Shigehiro Demura, Masashi Yoneda, Takashi Takeda, Yoshiyu J Endocr Soc Adrenal Renovascular hypertension (RVHT) is an important and potentially treatable form of resistant hypertension. Hypercortisolemia could also cause hypertension and diabetes mellitus. We experienced a case wherein adrenalectomy markedly improved blood pressure and plasma glucose levels in a patient with RVHT and subclinical Cushing’s syndrome. A 62-year-old Japanese man had been treated for hypertension and diabetes mellitus for 10 years. He was hospitalized because of disturbance in consciousness. His blood pressure (BP) was 236/118 mmHg; pulse rate, 132 beats/min; and plasma glucose level, 712 mg/dl. Abdominal computed tomography scanning revealed the presence of bilateral adrenal masses and left atrophic kidney. Abdominal magnetic resonance angiography demonstrated marked stenosis of the left main renal artery. The patient was subsequently diagnosed with atherosclerotic RVHT with left renal artery stenosis. Bilateral adrenal masses were immunohistologically identified as potential sites for cortisol overproduction. Therefore, laparoscopic left nephrectomy and adrenalectomy were simultaneously performed resulting in improved BP and glucose levels. Pathological studies revealed the presence of multiple cortisol-producing adrenal nodules and aldosterone-producing cell clusters in the adjacent left adrenal cortex. In the present case, activated renin-angiotensin-aldosterone system and cortisol overproduction resulted in severe hypertension, which was managed with simultaneous unilateral nephrectomy and adrenalectomy. Oxford University Press 2020-05-08 /pmc/articles/PMC7207581/ http://dx.doi.org/10.1210/jendso/bvaa046.2035 Text en © Endocrine Society 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Adrenal
Higashitani, Takuya
Aono, Daisuke
Kometani, Mitsuhiro
Karashima, Shigehiro
Demura, Masashi
Yoneda, Takashi
Takeda, Yoshiyu
MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses
title MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses
title_full MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses
title_fullStr MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses
title_full_unstemmed MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses
title_short MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses
title_sort mon-lb043 a case of renovascular hypertension with cortisol-producing adrenal masses
topic Adrenal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207581/
http://dx.doi.org/10.1210/jendso/bvaa046.2035
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