MON-722 Cross-Species Glucocorticoid-Sensitive Posterior Dentate Gyrus Gene Network: Developing a Polygenic Score Associated to Susceptibility to Depression After Early Life Adversity Exposure in Humans

Exposure to stress during the life-course has consistently been associated with neuropsychological disorders, but the precise role of stress released glucocorticoids remains unclear in this context. We aimed at using hippocampal gene expression data from macaques to identify clusters of genes sensib...

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Detalles Bibliográficos
Autores principales: Arcego, Danusa Mar, O’Toole, Nick, Buschdorf, Jan-Paul, Rayan, Nirmala Arul, Barth, Barbara, Pokhvisneva, Irina, Wang, Zihan, Patel, Sachin, Filho, Euclides José de Mendonça, de Lima, Randriely Merscher Sobreira, Dalmaz, Carla, Silveira, Patricia Pelufo, Meaney, Michael Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genetics and Development (including Gene Regulation)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207636/
http://dx.doi.org/10.1210/jendso/bvaa046.1052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207636/
http://dx.doi.org/10.1210/jendso/bvaa046.1052

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