SUN-240 Female Mice Lacking Brain Insulin Production Exhibit Learning Deficits, Anxiety, and Reduced Hippocampal Cyclin D1 Expression

Insulin dysregulation independently underlies diabetes and Alzheimer’s Disease (AD) pathology. However, the former has also been shown to be a risk factor for the latter. The ancestral insulin gene (Ins2), but not the pancreas-specific Ins1gene, is transcribed locally within the brain in mice. We co...

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Detalles Bibliográficos
Autores principales: Baehring, Stella Katharina, O’Leary, Timothy P, Holenka, Danae M, Li, Hong, Kim, Kyungchan, Mehran, Arya E, Pavlidis, Paul, Kim, Eun-Kyoung, Bamji, Shernaz X, Johnson, James D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207865/
http://dx.doi.org/10.1210/jendso/bvaa046.1066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207865/
http://dx.doi.org/10.1210/jendso/bvaa046.1066

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