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SAT-718 Inhibition of Androgen Receptor Activity by DDE Is Affected by Mutations in the BF3 Site

The androgen receptor (AR) plays an important role in the development of the male phenotype and traits. Some diphenyl compounds inhibit AR activity by binding to a hydrophobic surface binding site, BF3. A similar diphenyl structure is found in 4,4’ DDT and its breakdown product 4,4’ DDE. Previous re...

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Detalles Bibliográficos
Autores principales:	Lozano, Andrea, Kotsikorou, Evangelia, Dean, Frank B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genetics and Development (including Gene Regulation)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208419/ http://dx.doi.org/10.1210/jendso/bvaa046.1648

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