SUN-221 Subclinical Alpha-1 Antitrypsin Deficiency Is Associated with Increased Free Cortisol Fraction in Plasma and Altered Glucocorticoid Delivery to Tissues

Background Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and controls the circulating free cortisol pool. Proteolytic cleavage by neutrophil elastase is proposed to reduce CBG binding affinity and increase free cortisol availability to inflamed tissues. The CORtisol NETwork...

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Detalles Bibliográficos
Autores principales: Boyle, Luke David, Nixon, Mark, Underhill, Caroline M, Hill, Lesley A, Homer, Natalie Z M, Andrew, Ruth, Hammond, Geoffrey L, Lewis, John G, Stimson, Roland H, Walker, Brian Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Adrenal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208476/
http://dx.doi.org/10.1210/jendso/bvaa046.1849

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