SUN-548 Ketone Bodies in Critical Illness Alter Cholesterol Synthesis in Skeletal Muscle, Interlinked with Protection Against Weakness

Background: Critically ill patients often develop muscle weakness, which hampers recovery. In septic mice, supplementing parenteral nutrition (PN) with ketone body 3-hydroxybutyrate (3HB) attenuated muscle weakness, but also normalized sepsis-induced low cholesterol(1). As 3HB can be metabolized int...

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Detalles Bibliográficos
Autores principales: Goossens, Chloë, Derde, Sarah, Perre, Sarah Vander, Weckx, Ruben, Boone, Marissa, Van den Berghe, Greet, Langouche, Lies
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Cardiovascular Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208583/
http://dx.doi.org/10.1210/jendso/bvaa046.881

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