SUN-LB52 The Protective Effects of Hepatocyte GH Receptor (GHR) Signaling Against Steatosis and Liver Injury Is Sexually Dimorphic and Autonomous of IGF1

GH dysregulation contributes to the development of non-alcoholic fatty liver disease (NAFLD), however debate remains as to the relative contribution of the direct vs indirect effects of GH, via IGF1. Mouse models with congenital, liver-specific knockout of the GHR, JAK2 or STAT5, as adults exhibit s...

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Detalles Bibliográficos
Autores principales: Sarmento-Cabral, Andre, del Rio-Moreno, Mercedes, Vazquez-Borrego, Mari C, Mahmood, Mariyah, Gutierrez-Casado, Elena, Guzman, Grace, Subbaiah, Papasani V, Cordoba-Chacon, Jose, Yakar, Shoshana, Kineman, Rhonda D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208591/
http://dx.doi.org/10.1210/jendso/bvaa046.2287

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