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SAT-308 Effect of Silibinin on ACTH Synthesis and Secretion in Human Adenomatous Corticotropes in Vitro

Silibinin, a milk thistle extract with known hepatoprotective effects, has recently been shown to act upon tumoral corticotropes and revert the Cushingoid phenotype in an allograft mouse model (Riebold et al 2015). Silbinin is known to inhibit HSP90 -a chaperone to the glucocorticoid receptor- there...

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Detalles Bibliográficos
Autores principales:	Cassarino, Maria Francesca, Sesta, Antonella, Libera, Laura, Bardelli, Donatella, Losa, Marco, Lasio, Giovanni, Giraldi, Francesca Pecori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Neuroendocrinology and Pituitary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208688/ http://dx.doi.org/10.1210/jendso/bvaa046.417

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