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OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)

Background: The Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) started in June 2016. As a follow-up study of comparing the quality of life (QoL) of the active surveillance (AS) and immediate surgery (OP) groups at 8 months (9.3±4.8 and 7.1±4...

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Autores principales: Shin, Soo Myoung, Kong, Sung Hye, Ryu, Junsun, Kim, Min Joo, Cho, Sun Wook, Song, Young Shin, Yi, Ka Hee, Park, Do Joon, Hwangbo, Yul, Lee, You Jin, Lee, Kyu Eun, Kim, Su‐jin, Jeong, Woo‐Jin, Chung, Eun‐Jae, Hah, Jeong Hun, Choi, June Young, Ryu, Chang Hwan, Jung, Yuh‐Seog, Lee, Eun Kyung, Park, Young Joo, Moon, Jae Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208702/
http://dx.doi.org/10.1210/jendso/bvaa046.1984
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author Shin, Soo Myoung
Kong, Sung Hye
Ryu, Junsun
Kim, Min Joo
Cho, Sun Wook
Song, Young Shin
Yi, Ka Hee
Park, Do Joon
Hwangbo, Yul
Lee, You Jin
Lee, Kyu Eun
Kim, Su‐jin
Jeong, Woo‐Jin
Chung, Eun‐Jae
Hah, Jeong Hun
Choi, June Young
Ryu, Chang Hwan
Jung, Yuh‐Seog
Lee, Eun Kyung
Park, Young Joo
Moon, Jae Hoon
author_facet Shin, Soo Myoung
Kong, Sung Hye
Ryu, Junsun
Kim, Min Joo
Cho, Sun Wook
Song, Young Shin
Yi, Ka Hee
Park, Do Joon
Hwangbo, Yul
Lee, You Jin
Lee, Kyu Eun
Kim, Su‐jin
Jeong, Woo‐Jin
Chung, Eun‐Jae
Hah, Jeong Hun
Choi, June Young
Ryu, Chang Hwan
Jung, Yuh‐Seog
Lee, Eun Kyung
Park, Young Joo
Moon, Jae Hoon
author_sort Shin, Soo Myoung
collection PubMed
description Background: The Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) started in June 2016. As a follow-up study of comparing the quality of life (QoL) of the active surveillance (AS) and immediate surgery (OP) groups at 8 months (9.3±4.8 and 7.1±4.2 months, respectively), here we aimed to compare the QoL between the AS and OP groups after 18 months (22.8±4.0 and 22.3±4.3 months, respectively) of follow-up. Methods: QoL of 108 participants who chose AS, 101 who underwent OP, twelve who changed from AS to OP was evaluated using a thyroid‐specific QoL questionnaire at diagnosis and during follow‐up (median 23 months). Results: The mean ages of the participants in the AS and OP groups were 47.7±11.0 and 45.1±10.0 years (p=0.075), respectively. At baseline, better physical (8.2±1.4 vs. 7.6±1.8, p=0.032), psychological (7.4±1.2 vs. 6.7±1.6, p=0.010), and total health (7.4±1.0 vs. 6.7±1.3, p=0.005) were observed in the AS group than in the OP group. After a mean follow up of 22.7±4.2 months, better physical (8.1±1.5 vs. 7.4±1.7, p=0.008), psychological (7.7±1.3 vs. 7.0±1.5, p=0.002), and total health (7.5±1.2 vs. 6.8±1.3, p=0.001) were observed in the AS group than in the OP group, whereas spiritual health was comparable between the two groups: compared with the AS group, the OP group experienced more alterations in appetite, sleep, menstrual cycle, voice, motor skill, weight, appearance, cold or heat tolerance, and body swelling. Furthermore, better QOL scores were observed in the AS group in self-concept, personal relationships, sexual life, work motivation, productivity and quality of work, feeling of isolation, driving, doing household chores, preparing meals and doing leisure activities after long term follow up. Conclusion: Patients who underwent AS had better QOL even after long term follow up. Low risk papillary thyroid microcarcinomas do not influence survival, however surgery related deterioration of QOL lasted long and did not improve even in late post-operative stages when patients were fully recovered from surgery. Keywords: Quality of life; papillary thyroid microcarcinoma; active surveillance; immediate surgery
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spelling pubmed-72087022020-05-13 OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro) Shin, Soo Myoung Kong, Sung Hye Ryu, Junsun Kim, Min Joo Cho, Sun Wook Song, Young Shin Yi, Ka Hee Park, Do Joon Hwangbo, Yul Lee, You Jin Lee, Kyu Eun Kim, Su‐jin Jeong, Woo‐Jin Chung, Eun‐Jae Hah, Jeong Hun Choi, June Young Ryu, Chang Hwan Jung, Yuh‐Seog Lee, Eun Kyung Park, Young Joo Moon, Jae Hoon J Endocr Soc Thyroid Background: The Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) started in June 2016. As a follow-up study of comparing the quality of life (QoL) of the active surveillance (AS) and immediate surgery (OP) groups at 8 months (9.3±4.8 and 7.1±4.2 months, respectively), here we aimed to compare the QoL between the AS and OP groups after 18 months (22.8±4.0 and 22.3±4.3 months, respectively) of follow-up. Methods: QoL of 108 participants who chose AS, 101 who underwent OP, twelve who changed from AS to OP was evaluated using a thyroid‐specific QoL questionnaire at diagnosis and during follow‐up (median 23 months). Results: The mean ages of the participants in the AS and OP groups were 47.7±11.0 and 45.1±10.0 years (p=0.075), respectively. At baseline, better physical (8.2±1.4 vs. 7.6±1.8, p=0.032), psychological (7.4±1.2 vs. 6.7±1.6, p=0.010), and total health (7.4±1.0 vs. 6.7±1.3, p=0.005) were observed in the AS group than in the OP group. After a mean follow up of 22.7±4.2 months, better physical (8.1±1.5 vs. 7.4±1.7, p=0.008), psychological (7.7±1.3 vs. 7.0±1.5, p=0.002), and total health (7.5±1.2 vs. 6.8±1.3, p=0.001) were observed in the AS group than in the OP group, whereas spiritual health was comparable between the two groups: compared with the AS group, the OP group experienced more alterations in appetite, sleep, menstrual cycle, voice, motor skill, weight, appearance, cold or heat tolerance, and body swelling. Furthermore, better QOL scores were observed in the AS group in self-concept, personal relationships, sexual life, work motivation, productivity and quality of work, feeling of isolation, driving, doing household chores, preparing meals and doing leisure activities after long term follow up. Conclusion: Patients who underwent AS had better QOL even after long term follow up. Low risk papillary thyroid microcarcinomas do not influence survival, however surgery related deterioration of QOL lasted long and did not improve even in late post-operative stages when patients were fully recovered from surgery. Keywords: Quality of life; papillary thyroid microcarcinoma; active surveillance; immediate surgery Oxford University Press 2020-05-08 /pmc/articles/PMC7208702/ http://dx.doi.org/10.1210/jendso/bvaa046.1984 Text en © Endocrine Society 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Thyroid
Shin, Soo Myoung
Kong, Sung Hye
Ryu, Junsun
Kim, Min Joo
Cho, Sun Wook
Song, Young Shin
Yi, Ka Hee
Park, Do Joon
Hwangbo, Yul
Lee, You Jin
Lee, Kyu Eun
Kim, Su‐jin
Jeong, Woo‐Jin
Chung, Eun‐Jae
Hah, Jeong Hun
Choi, June Young
Ryu, Chang Hwan
Jung, Yuh‐Seog
Lee, Eun Kyung
Park, Young Joo
Moon, Jae Hoon
OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)
title OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)
title_full OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)
title_fullStr OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)
title_full_unstemmed OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)
title_short OR28-06 Assessment of Long Term Quality of Life According to Treatment Options in Low Risk Papillary Thyroid Microcarcinoma Patients ‐ Active Surveillance or Immediate Surgery, (A Follow up Interim Analysis of Maestro)
title_sort or28-06 assessment of long term quality of life according to treatment options in low risk papillary thyroid microcarcinoma patients ‐ active surveillance or immediate surgery, (a follow up interim analysis of maestro)
topic Thyroid
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208702/
http://dx.doi.org/10.1210/jendso/bvaa046.1984
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