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SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma

Background: Pheochromocytoma is a rare catecholamine-producing tumor of chromaffin cells in the adrenal medulla or of a paraganglion. Typically it presents with sustained or paroxysmal hypertension, severe headaches, palpitations and sweating due to hormone excess. However, the presentation can be v...

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Autores principales: Mohammad, Nazar, Frith, Margaret, Wilhelm, Olayinka Olawale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208708/
http://dx.doi.org/10.1210/jendso/bvaa046.231
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author Mohammad, Nazar
Frith, Margaret
Wilhelm, Olayinka Olawale
author_facet Mohammad, Nazar
Frith, Margaret
Wilhelm, Olayinka Olawale
author_sort Mohammad, Nazar
collection PubMed
description Background: Pheochromocytoma is a rare catecholamine-producing tumor of chromaffin cells in the adrenal medulla or of a paraganglion. Typically it presents with sustained or paroxysmal hypertension, severe headaches, palpitations and sweating due to hormone excess. However, the presentation can be variable and can mimic many other diseases. If left undiagnosed or untreated, it can lead to life-threatening consequences. Case Presentation:A 35 year old female with significant past medical history of migraine headaches, poorly controlled hypertension and a recent new onset seizure, presented with progressive worsening shortness of breath and persistent abdominal pain following a gastrointestinal illness. She also reported diaphoresis, cold fingers and toes, abnormal weight gain, and orthostatic symptoms that gradually worsened for two months prior to presentation. Laboratory evaluation revealed lactic acidosis, leukocytosis, and hypokalemia. Subsequently, a CT scan of the abdomen was performed that revealed an adrenal mass with significant elevation in urine metanephrines. As a result, the patient was diagnosed with pheochromocytoma and successfully treated with laparoscopic left adrenalectomy. Conclusion: Pheochromocytoma is a rare but can be life threatening if left undiagnosed. It is of utmost importance for clinicians to keep in mind such unusual presentation of a potentially life threatening tumor. To the best of our knowledge, this is an unusual presentation of Pheochromocytoma with severe lactic acidosis.
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spelling pubmed-72087082020-05-13 SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma Mohammad, Nazar Frith, Margaret Wilhelm, Olayinka Olawale J Endocr Soc Tumor Biology Background: Pheochromocytoma is a rare catecholamine-producing tumor of chromaffin cells in the adrenal medulla or of a paraganglion. Typically it presents with sustained or paroxysmal hypertension, severe headaches, palpitations and sweating due to hormone excess. However, the presentation can be variable and can mimic many other diseases. If left undiagnosed or untreated, it can lead to life-threatening consequences. Case Presentation:A 35 year old female with significant past medical history of migraine headaches, poorly controlled hypertension and a recent new onset seizure, presented with progressive worsening shortness of breath and persistent abdominal pain following a gastrointestinal illness. She also reported diaphoresis, cold fingers and toes, abnormal weight gain, and orthostatic symptoms that gradually worsened for two months prior to presentation. Laboratory evaluation revealed lactic acidosis, leukocytosis, and hypokalemia. Subsequently, a CT scan of the abdomen was performed that revealed an adrenal mass with significant elevation in urine metanephrines. As a result, the patient was diagnosed with pheochromocytoma and successfully treated with laparoscopic left adrenalectomy. Conclusion: Pheochromocytoma is a rare but can be life threatening if left undiagnosed. It is of utmost importance for clinicians to keep in mind such unusual presentation of a potentially life threatening tumor. To the best of our knowledge, this is an unusual presentation of Pheochromocytoma with severe lactic acidosis. Oxford University Press 2020-05-08 /pmc/articles/PMC7208708/ http://dx.doi.org/10.1210/jendso/bvaa046.231 Text en © Endocrine Society 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Tumor Biology
Mohammad, Nazar
Frith, Margaret
Wilhelm, Olayinka Olawale
SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma
title SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma
title_full SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma
title_fullStr SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma
title_full_unstemmed SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma
title_short SUN-933 Lactic Acidosis as a Rare and Unusual Presentation of Pheochromocytoma
title_sort sun-933 lactic acidosis as a rare and unusual presentation of pheochromocytoma
topic Tumor Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208708/
http://dx.doi.org/10.1210/jendso/bvaa046.231
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