SUN-651 Murine Cecal Ligation and Puncture (CLP) Perturbs Phosphorylation of Insulin Receptor Substrate 2 (IRS-2)

Hyperglycemia is a characteristic finding in sepsis, and its presence worsens outcome (1). Patients with sepsis need larger doses of insulin to reduce glucose levels. This abnormality has been termed “insulin resistance” but the molecular mechanism by which sepsis attenuates the insulin signaling pa...

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Detalles Bibliográficos
Autores principales: Mathew, Deepa, Barillas, Julia, Fernandes, Tiago, Kelly, Alexander, Yaipen, Omar, Abraham, Mabel, Deutschman, Clifford
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diabetes Mellitus and Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208800/
http://dx.doi.org/10.1210/jendso/bvaa046.650

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