SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency

Introduction: Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. Case: A 7-year-old boy was referred for short stature, an...

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Autores principales: Rochtus, Anne Maria, Vinckx, Joseph, de Zegher, Francis Edouard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209085/
http://dx.doi.org/10.1210/jendso/bvaa046.510
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author Rochtus, Anne Maria
Vinckx, Joseph
de Zegher, Francis Edouard
author_facet Rochtus, Anne Maria
Vinckx, Joseph
de Zegher, Francis Edouard
author_sort Rochtus, Anne Maria
collection PubMed
description Introduction: Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. Case: A 7-year-old boy was referred for short stature, and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth. Discussion: The present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored.
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spelling pubmed-72090852020-05-13 SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency Rochtus, Anne Maria Vinckx, Joseph de Zegher, Francis Edouard J Endocr Soc Neuroendocrinology and Pituitary Introduction: Intracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity. Case: A 7-year-old boy was referred for short stature, and proved to be partially growth-hormone deficient. Magnetic resonance imaging (MRI) revealed a lipoma in the paramedian hypothalamus. Growth hormone treatment resulted in swift and uncomplicated catch-up growth. Discussion: The present case appears to be the first to link hypothalamic lipoma to GH deficiency. The neuro-endocrine pathophysiology underpinning this link remains to be explored. Oxford University Press 2020-05-08 /pmc/articles/PMC7209085/ http://dx.doi.org/10.1210/jendso/bvaa046.510 Text en © Endocrine Society 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Neuroendocrinology and Pituitary
Rochtus, Anne Maria
Vinckx, Joseph
de Zegher, Francis Edouard
SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency
title SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency
title_full SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency
title_fullStr SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency
title_full_unstemmed SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency
title_short SAT-240 Hypothalamic Lipoma and Growth Hormone Deficiency
title_sort sat-240 hypothalamic lipoma and growth hormone deficiency
topic Neuroendocrinology and Pituitary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209085/
http://dx.doi.org/10.1210/jendso/bvaa046.510
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AT vinckxjoseph sat240hypothalamiclipomaandgrowthhormonedeficiency
AT dezegherfrancisedouard sat240hypothalamiclipomaandgrowthhormonedeficiency

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