SUN-646 A Novel Population of FOXO1-Expressing Cells in the Stomach Controls Cell Plasticity by Regulating the Cyclin CCNE1

A promising new therapy for type 1 diabetes is the reprogramming of gut enteroendocrine cells into cells that produce insulin. The mechanism by which gut epithelial cells are converted into cells that make insulin remains unknown. We have previously found that elimination of Foxo1 in neurogenin3 (Ng...

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Detalles Bibliográficos
Autores principales: McKimpson, Wendy M, Kuo, Taiyi, Kitamoto, Takumi, Higuchi, Sei, Haeusler, Rebecca, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diabetes Mellitus and Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209326/
http://dx.doi.org/10.1210/jendso/bvaa046.528

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