OR25-03 The Effects of Crinecerfont (NBI-74788), a Novel CRF1 Receptor Antagonist, on Adrenal Androgens and Precursors in Patients with Classic Congenital Adrenal Hyperplasia: Results from A Multiple-Dose Phase 2 Study

Introduction: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD CAH) is a rare autosomal recessive disease that results in impaired cortisol synthesis and excess androgen production. Compounds that inhibit adrenocorticotropic hormone (ACTH) release could reduce adrenal a...

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Detalles Bibliográficos
Autores principales: Auchus, Richard J, Sarafoglou, Kyriakie, Fechner, Patricia Y, Vogiatzi, Maria, Giri, Nagdeep, Roberts, Eiry, Sturgeon, Julia, Farber, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Adrenal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209526/
http://dx.doi.org/10.1210/jendso/bvaa046.221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209526/
http://dx.doi.org/10.1210/jendso/bvaa046.221

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