Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis

Corticosteroid is the treatment of choice for severe alcoholic hepatitis; however, it can also lead to severe life-threatening infection. We report a 28-year-old severe alcoholic hepatitis patient who did not achieve a satisfactory improvement of the liver function by corticosteroid use but obtained...

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Detalles Bibliográficos
Autores principales: Tak, Kwon Yong, Sung, Pil Soo, Nam, Hee Chul, Jang, Jeong Won, Choi, Jong Young, Yoon, Seung Kew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209802/
https://www.ncbi.nlm.nih.gov/pubmed/32440529
http://dx.doi.org/10.14309/crj.0000000000000337
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author Tak, Kwon Yong
Sung, Pil Soo
Nam, Hee Chul
Jang, Jeong Won
Choi, Jong Young
Yoon, Seung Kew
author_facet Tak, Kwon Yong
Sung, Pil Soo
Nam, Hee Chul
Jang, Jeong Won
Choi, Jong Young
Yoon, Seung Kew
author_sort Tak, Kwon Yong
collection PubMed
description Corticosteroid is the treatment of choice for severe alcoholic hepatitis; however, it can also lead to severe life-threatening infection. We report a 28-year-old severe alcoholic hepatitis patient who did not achieve a satisfactory improvement of the liver function by corticosteroid use but obtained a significant improvement of the liver function by intravenous immunoglobulin. Intravenous immunoglobulin was administered to control infection after prolonged corticosteroid usage; however, it led to an unexpected remarkable decrease in the serum total bilirubin level and restored the responsiveness to the additional corticosteroid used after the resolution of the infection.
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spelling pubmed-72098022020-05-21 Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis Tak, Kwon Yong Sung, Pil Soo Nam, Hee Chul Jang, Jeong Won Choi, Jong Young Yoon, Seung Kew ACG Case Rep J Case Report Corticosteroid is the treatment of choice for severe alcoholic hepatitis; however, it can also lead to severe life-threatening infection. We report a 28-year-old severe alcoholic hepatitis patient who did not achieve a satisfactory improvement of the liver function by corticosteroid use but obtained a significant improvement of the liver function by intravenous immunoglobulin. Intravenous immunoglobulin was administered to control infection after prolonged corticosteroid usage; however, it led to an unexpected remarkable decrease in the serum total bilirubin level and restored the responsiveness to the additional corticosteroid used after the resolution of the infection. Wolters Kluwer 2020-03-02 /pmc/articles/PMC7209802/ /pubmed/32440529 http://dx.doi.org/10.14309/crj.0000000000000337 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Tak, Kwon Yong
Sung, Pil Soo
Nam, Hee Chul
Jang, Jeong Won
Choi, Jong Young
Yoon, Seung Kew
Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis
title Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis
title_full Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis
title_fullStr Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis
title_full_unstemmed Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis
title_short Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis
title_sort unexpected improvement of liver function by intravenous immunoglobulin in a steroid-experienced severe alcoholic hepatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209802/
https://www.ncbi.nlm.nih.gov/pubmed/32440529
http://dx.doi.org/10.14309/crj.0000000000000337
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