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Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line

Poly (ADP-ribose) polymerase 1 (PARP1) plays important roles in single strand DNA repair. PARP1 inhibitors enhance the effects of DNA damaging drugs in homologous recombination-deficient tumors including tumors with breast cancer susceptibility gene (BRCA1) mutation. Nutlin-3a, an analog of cis-imid...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Masaki, Ishizaki, Yuka, Owaki, Mika, Matsumoto, Yoko, Kakiyama, Yuri, Hoshino, Shunsuke, Tagawa, Ryoma, Sudo, Yuka, Okita, Naoyuki, Akimoto, Kazunori, Higami, Yoshikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210013/ https://www.ncbi.nlm.nih.gov/pubmed/32405340 http://dx.doi.org/10.18632/oncotarget.27581

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