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Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving
OBJECTIVE: Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in the brain of postherpetic neuralgia (PHN) patients are changeable. METHODS: Fifteen successfully treated PHN patients were enrolled; the br...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210030/ https://www.ncbi.nlm.nih.gov/pubmed/32440196 http://dx.doi.org/10.2147/JPR.S246745 |
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author | Zhang, Yi Cao, Song Yuan, Jie Song, Ganjun Yu, Tian Liang, Xiaoli |
author_facet | Zhang, Yi Cao, Song Yuan, Jie Song, Ganjun Yu, Tian Liang, Xiaoli |
author_sort | Zhang, Yi |
collection | PubMed |
description | OBJECTIVE: Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in the brain of postherpetic neuralgia (PHN) patients are changeable. METHODS: Fifteen successfully treated PHN patients were enrolled; the brain activity and structural abnormalities were detected and compared before and 6 months after treatment. The functional parameters were evaluated with resting-state functional MRI technique, i.e., the regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF). Structural changes were detected with voxel-based morphometry (VBM) and diffusion kurtosis imaging (DKI). RESULTS: Six months after pain relieving, PHN brain showed different ReHo and fALFF values in the frontal lobe, caudate, supramarginal gyrus, anterior cingulate cortex (ACC), cuneus, middle temporal gyrus, and cerebellum. In addition, VBM intensity in the cerebellum increased; DKI values decreased in the thalamus and increased in the temporal lobe after successful treatment. CONCLUSION: Six months after pain relieving, functional and structural changes exist in PHN brain. Changes in some differential areas in PHN brain, such as ACC, frontal lobe, thalamus, and temporal lobe indicate that the central plasticity may be reversible after chronic pain relieving. |
format | Online Article Text |
id | pubmed-7210030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-72100302020-05-21 Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving Zhang, Yi Cao, Song Yuan, Jie Song, Ganjun Yu, Tian Liang, Xiaoli J Pain Res Original Research OBJECTIVE: Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in the brain of postherpetic neuralgia (PHN) patients are changeable. METHODS: Fifteen successfully treated PHN patients were enrolled; the brain activity and structural abnormalities were detected and compared before and 6 months after treatment. The functional parameters were evaluated with resting-state functional MRI technique, i.e., the regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF). Structural changes were detected with voxel-based morphometry (VBM) and diffusion kurtosis imaging (DKI). RESULTS: Six months after pain relieving, PHN brain showed different ReHo and fALFF values in the frontal lobe, caudate, supramarginal gyrus, anterior cingulate cortex (ACC), cuneus, middle temporal gyrus, and cerebellum. In addition, VBM intensity in the cerebellum increased; DKI values decreased in the thalamus and increased in the temporal lobe after successful treatment. CONCLUSION: Six months after pain relieving, functional and structural changes exist in PHN brain. Changes in some differential areas in PHN brain, such as ACC, frontal lobe, thalamus, and temporal lobe indicate that the central plasticity may be reversible after chronic pain relieving. Dove 2020-05-04 /pmc/articles/PMC7210030/ /pubmed/32440196 http://dx.doi.org/10.2147/JPR.S246745 Text en © 2020 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhang, Yi Cao, Song Yuan, Jie Song, Ganjun Yu, Tian Liang, Xiaoli Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving |
title | Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving |
title_full | Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving |
title_fullStr | Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving |
title_full_unstemmed | Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving |
title_short | Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving |
title_sort | functional and structural changes in postherpetic neuralgia brain before and six months after pain relieving |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210030/ https://www.ncbi.nlm.nih.gov/pubmed/32440196 http://dx.doi.org/10.2147/JPR.S246745 |
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