Cargando…

Tetraspanin CD82 drives Acute Myeloid Leukemia chemoresistance by modulating Protein Kinase C alpha and β1 integrin activation

A principal challenge in treating acute myeloid leukemia (AML) is chemotherapy refractory disease. As such, there remains a critical need to identify key regulators of chemotherapy resistance in AML. In this study, we demonstrate that the membrane scaffold, CD82, contributes to the chemoresistant ph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Floren, Muskan, Cruz, Sebastian Restrepo, Termini, Christina M., Marjon, Kristopher D., Lidke, Keith A., Gillette, Jennifer M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210072/ https://www.ncbi.nlm.nih.gov/pubmed/32203165 http://dx.doi.org/10.1038/s41388-020-1261-0

Ejemplares similares

Tetraspanin CD82 Regulates the Spatiotemporal Dynamics of PKCα in Acute Myeloid Leukemia
por: Termini, Christina M., et al.
Publicado: (2016)

Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin
por: Marjon, Kristopher D., et al.
Publicado: (2015)

The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells
por: Saito-Reis, Chelsea A., et al.
Publicado: (2018)

The membrane scaffold CD82 regulates cell adhesion by altering α4 integrin stability and molecular density
por: Termini, Christina M., et al.
Publicado: (2014)

Tetraspanins Function as Regulators of Cellular Signaling
por: Termini, Christina M., et al.
Publicado: (2017)

Characterization of Integrin–Tetraspanin Adhesion Complexes: Role of Tetraspanins in Integrin Signaling
por: Berditchevski, Fedor, et al.
Publicado: (1999)

Tetraspanin CD82 regulates S1PR(1)-mediated hematopoietic stem and progenitor cell mobilization
por: Saito-Reis, Chelsea A., et al.
Publicado: (2021)

The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia
por: Johansen, Silje, et al.
Publicado: (2018)

Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
por: Bergsma, Alexis, et al.
Publicado: (2019)

Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation
por: McGowan, Erin N.S., et al.
Publicado: (2022)

MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway
por: Li, Jun, et al.
Publicado: (2020)

Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia
por: Boyer, Thomas, et al.
Publicado: (2016)

Palmitoylation supports assembly and function of integrin–tetraspanin complexes
por: Yang, Xiuwei, et al.
Publicado: (2004)

Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1
por: Ordas, Laura, et al.
Publicado: (2021)

Notch signalling drives bone marrow stromal cell-mediated chemoresistance in acute myeloid leukemia
por: Kamga, Paul Takam, et al.
Publicado: (2016)

Lysosome-mediated chemoresistance in acute myeloid leukemia
por: Cuesta-Casanovas, Laia, et al.
Publicado: (2022)

Tetraspanin Family Member, CD82, Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells
por: Nishioka, Chie, et al.
Publicado: (2015)

Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets
por: Stipp, Christopher S.
Publicado: (2010)

Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
por: Hall, Arielle, et al.
Publicado: (2020)

Integrin-alpha10 drives tumorigenesis in sarcoma
por: Okada, Tomoyo, et al.
Publicado: (2017)

Integrin-independent support of cancer drug resistance by tetraspanin CD151
por: Hwang, Soonyean, et al.
Publicado: (2019)

Role of the metastasis suppressor tetraspanin CD82/KAI 1 in regulation of signalling in breast cancer cells
por: Odintsova, E, et al.
Publicado: (2006)

Transcriptomic profile of intrinsically chemoresistant acute myeloid leukemia patients
por: Horibata, Sachi
Publicado: (2019)

Tetraspanin CD82 Inhibits Protrusion and Retraction in Cell Movement by Attenuating the Plasma Membrane-Dependent Actin Organization
por: Liu, Wei M., et al.
Publicado: (2012)

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151()()
por: Tilghman, Jessica, et al.
Publicado: (2016)

Tetraspanin Scaffold Proteins Function as Key Regulators of Hematopoietic Stem Cells
por: Balise, Victoria D., et al.
Publicado: (2020)

Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement
por: Huang, Chao, et al.
Publicado: (2019)

Role of Integrin Alpha4 in Drug Resistance of Leukemia
por: Shishido, Stephanie, et al.
Publicado: (2014)

Tetraspanin 8-Rictor-Integrin α3 Complex Is Required for Glioma Cell Migration
por: Pan, Si-Jian, et al.
Publicado: (2015)

microRNAs and Acute Myeloid Leukemia Chemoresistance: A Mechanistic Overview
por: Gabra, Martino Marco, et al.
Publicado: (2017)

Targeting chemoresistance and mitochondria-dependent metabolic reprogramming in acute myeloid leukemia
por: Feng, Lili, et al.
Publicado: (2023)

Chronic lymphocytic leukemia with clinical debut as neurological involvement: a rare phenomenon and the need for better predictive markers
por: Rojas-Hernandez, Cristhiam M., et al.
Publicado: (2017)

Integrin Signaling in Cancer Cell Survival and Chemoresistance
por: Aoudjit, Fawzi, et al.
Publicado: (2012)

Circulating Tetraspanins: From Markers to Mechanisms Driving Systemic Exercise Adaptation
por: Easterday, Darby S, et al.
Publicado: (2023)

Lin28A/CENPE Promoting the Proliferation and Chemoresistance of Acute Myeloid Leukemia
por: Shi, Mingyue, et al.
Publicado: (2021)

TETRASPANINs in Plants
por: Reimann, Ronny, et al.
Publicado: (2017)

The CD9/CD81 Tetraspanin Complex and Tetraspanin CD151 Regulate α3β1 Integrin-Dependent Tumor Cell Behaviors by Overlapping but Distinct Mechanisms
por: Gustafson-Wagner, Elisabeth, et al.
Publicado: (2013)

Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells
por: Luo, Wu, et al.
Publicado: (2016)

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
por: Caiado, Francisco, et al.
Publicado: (2019)

Prolactin receptor signaling induces acquisition of chemoresistance and reduces clonogenicity in acute myeloid leukemia
por: Cuesta-Casanovas, Laia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3ipaelc13dod8sp8i9l95293ja