Cargando…
NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin
Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here, we demonstrate a unique protumorigenic niche in...
Autores principales: | Williams, Mark, Liu, Xinhui, Zhang, Yueqi, Reske, Jake, Bahal, Devika, Gohl, Trevor G., Hollern, Daniel, Ensink, Elliot, Kiupel, Matti, Luo, Rongcheng, Das, Rupali, Xiao, Hua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210077/ https://www.ncbi.nlm.nih.gov/pubmed/32203160 http://dx.doi.org/10.1038/s41388-020-1256-x |
Ejemplares similares
-
p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin
por: Molnar, Zoltan, et al.
Publicado: (2014) -
NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
por: Zhang, Yueqi, et al.
Publicado: (2023) -
Epigenetic Regulation of p21(cip1/waf1) in Human Cancer
por: Ocker, Matthias, et al.
Publicado: (2019) -
Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.
por: Koopmann, J., et al.
Publicado: (1995) -
Expression of p21 (WAF1/CIP1) protein in clinical thyroid tissues.
por: Ito, Y., et al.
Publicado: (1996)