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Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012
BACKGROUND: Secondhand smoke (SHS) may be related to worse outcomes in chronic obstructive pulmonary disease (COPD), but the reported SHS prevalence in different studies varied from 27% to 65% and the effects of SHS are still questionable among these patients. The study aims were to estimate the obj...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210150/ https://www.ncbi.nlm.nih.gov/pubmed/32395489 http://dx.doi.org/10.21037/atm.2020.03.145 |
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author | Fu, Zhen Jiang, Hongwei Xu, Zhongyu Li, Hongyu Wu, Nanjin Yin, Ping |
author_facet | Fu, Zhen Jiang, Hongwei Xu, Zhongyu Li, Hongyu Wu, Nanjin Yin, Ping |
author_sort | Fu, Zhen |
collection | PubMed |
description | BACKGROUND: Secondhand smoke (SHS) may be related to worse outcomes in chronic obstructive pulmonary disease (COPD), but the reported SHS prevalence in different studies varied from 27% to 65% and the effects of SHS are still questionable among these patients. The study aims were to estimate the objective SHS prevalence and explore the SHS impact on outcomes among COPD patients without active smoking. METHODS: A cross-sectional design combined with longitudinal death outcome. We selected COPD patients over 40 years old based on the spirometry from National Health and Nutrition Examination Survey (2007–2012), and used the tobacco-specific biomarkers [cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol] to determine exposure statuses (active smoking, SHS exposure, or no smoke exposure). Then we estimated the short-term (past 2–4 days) and medium-term (past 6–12 weeks) SHS prevalence among 334 patients without active smoking. Weighted multiple regressions were performed to assess the associations between medium-term SHS exposure and outcomes (symptoms, health status, medical institution visits, and death). RESULTS: Among the patients without active smoking, the objective prevalence rates of short-term and medium-term SHS were 66.65% [95% confidence interval (CI), 59.63–73.67%] and 34.91% (95% CI, 28.86%–40.96%), respectively. Medium-term SHS exposure showed a significant effect (odds ratio, 3.57; 95% CI, 1.22–10.40) on more chronic coughing after adjusting for the covariates and indicated a trend of unadjusted increasing death risk (log-rank test, P=0.01). CONCLUSIONS: Among COPD patients without active smoking, both short-term and medium-term SHS exposure are prevalent. Chronic cough may be the most susceptible patient-centred outcome related to medium-term SHS exposure. The crude longitudinal trend of elevated death risk associated with medium-term SHS exposure deserves further study. |
format | Online Article Text |
id | pubmed-7210150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-72101502020-05-11 Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 Fu, Zhen Jiang, Hongwei Xu, Zhongyu Li, Hongyu Wu, Nanjin Yin, Ping Ann Transl Med Original Article BACKGROUND: Secondhand smoke (SHS) may be related to worse outcomes in chronic obstructive pulmonary disease (COPD), but the reported SHS prevalence in different studies varied from 27% to 65% and the effects of SHS are still questionable among these patients. The study aims were to estimate the objective SHS prevalence and explore the SHS impact on outcomes among COPD patients without active smoking. METHODS: A cross-sectional design combined with longitudinal death outcome. We selected COPD patients over 40 years old based on the spirometry from National Health and Nutrition Examination Survey (2007–2012), and used the tobacco-specific biomarkers [cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol] to determine exposure statuses (active smoking, SHS exposure, or no smoke exposure). Then we estimated the short-term (past 2–4 days) and medium-term (past 6–12 weeks) SHS prevalence among 334 patients without active smoking. Weighted multiple regressions were performed to assess the associations between medium-term SHS exposure and outcomes (symptoms, health status, medical institution visits, and death). RESULTS: Among the patients without active smoking, the objective prevalence rates of short-term and medium-term SHS were 66.65% [95% confidence interval (CI), 59.63–73.67%] and 34.91% (95% CI, 28.86%–40.96%), respectively. Medium-term SHS exposure showed a significant effect (odds ratio, 3.57; 95% CI, 1.22–10.40) on more chronic coughing after adjusting for the covariates and indicated a trend of unadjusted increasing death risk (log-rank test, P=0.01). CONCLUSIONS: Among COPD patients without active smoking, both short-term and medium-term SHS exposure are prevalent. Chronic cough may be the most susceptible patient-centred outcome related to medium-term SHS exposure. The crude longitudinal trend of elevated death risk associated with medium-term SHS exposure deserves further study. AME Publishing Company 2020-04 /pmc/articles/PMC7210150/ /pubmed/32395489 http://dx.doi.org/10.21037/atm.2020.03.145 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Fu, Zhen Jiang, Hongwei Xu, Zhongyu Li, Hongyu Wu, Nanjin Yin, Ping Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 |
title | Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 |
title_full | Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 |
title_fullStr | Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 |
title_full_unstemmed | Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 |
title_short | Objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the U.S. National Health and Nutrition Examination Survey (NHANES) 2007–2012 |
title_sort | objective secondhand smoke exposure in chronic obstructive pulmonary disease patients without active smoking: the u.s. national health and nutrition examination survey (nhanes) 2007–2012 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210150/ https://www.ncbi.nlm.nih.gov/pubmed/32395489 http://dx.doi.org/10.21037/atm.2020.03.145 |
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