Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Our early-life environment has a profound influence on developing organs that impacts metabolic function and determines disease susceptibility across the life-course. Using a rat model for exposure to an endocrine disrupting chemical (EDC), we show that early-life chemical exposure causes metabolic...

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Detalles Bibliográficos
Autores principales: Treviño, Lindsey S., Dong, Jianrong, Kaushal, Ahkilesh, Katz, Tiffany A., Jangid, Rahul Kumar, Robertson, Matthew J., Grimm, Sandra L., Ambati, Chandra Shekar R., Putluri, Vasanta, Cox, Aaron R., Kim, Kang Ho, May, Thaddeus D., Gallo, Morgan R., Moore, David D., Hartig, Sean M., Foulds, Charles E., Putluri, Nagireddy, Coarfa, Cristian, Walker, Cheryl Lyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210260/
https://www.ncbi.nlm.nih.gov/pubmed/32385268
http://dx.doi.org/10.1038/s41467-020-15847-z

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